Dietary Hyaluronic Acid Migrates into the Skin of Rats

Table 1

Radioactivity concentration in plasma after single oral or intravenous administration of ¹⁴C hyaluronic acid to rats (dose: p.o.; 25 mg/kg, IV; 10 mg/kg).

Time	Radioactivity concentration
	(g eq. of hyaluronic acid/mL)
	p.o.	i.v.
5 min	N.D.
15	N.D.
30	N.D.
1 hr	N.D.
2	N.D.
4
8
24
48
72
96
120
144
168
Detection limit	0.1	0.1
(hr)		—
(g eq./mL)		—
(g eq./mL)	—
(5 min–8 hr) (hr)	—
(24–168 hr) (day)
AUC (g eq.·hr/mL)
(0–168 hr)
(0–)

Data are expressed as the mean values ± S.D. of three animals.
N.D.: not detected.
—: not determined.