Dietary Hyaluronic Acid Migrates into the Skin of Rats
Table 2
Cumulative excretion of radioactivity in urine, feces, and expired air as 14CO2 after single oral administration of 14C hyaluronic acid to rats (dose: 25 mg/kg).
Time (hr)
Excretion of radioactivity (% of dose)
Urine
Feces
Expried air
Total
0–4
0.0 ± 0.0
—
1.5 ± 1.2
—
8
1.0 ± 0.3
—
45.9 ± 1.9
—
24
2.5 ± 0.3
7.8 ± 1.6
70.7 ± 1.2
81.1 ± 1.5
48
2.7 ± 0.2
11.0 ± 1.0
73.4 ± 1.3
87.0 ± 0.9
72
2.8 ± 0.2
11.4 ± 1.0
74.7 ± 1.5
88.8 ± 0.9
96
2.9 ± 0.2
11.6 ± 1.0
75.4 ± 1.5
89.9 ± 1.0
120
2.9 ± 0.2
11.7 ± 1.0
75.8 ± 1.5
90.4 ± 1.0
144
2.9 ± 0.3
11.8 ± 1.0
76.2 ± 1.5
90.9 ± 1.0
168
3.0 ± 0.2
11.9 ± 1.0
76.5 ± 1.6
91.3 ± 1.0
Carcass (168 hr)
8.8 ± 0.6
Data are expressed as the mean values ± S.D. of three animals. —: not determined.
