Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage

Figure 3

PCA pretreatment ameliorated intestinal I/R-induced systemic inflammation, hepatic dysfunction, and NFκB activation. ((a) and (b)) Alterations of IL-6, TNF-α, ALT, and AST in the serum, 𝑛=10. (c) Western blot analysis of nuclear NFκB p65 in the intestine, 𝑛=3. (d) Western blot analysis of nuclear NFκB p65 in the liver, 𝑛=3. Results are presented as the mean ± SD. **𝑃<0.01 versus sham group; ^#𝑃<0.05 versus I/R group; ^##𝑃<0.01 versus I/R group. 1 indicates Sham; 2, I/R; 3, Sham + PCA (H); 4, I/R + PCA (L); 5, I/R + PCA (H).

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