Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage

Figure 6

PCA pretreatment regulated the oxidative-stress regulators and apoptotic factors of p66shc pathway. Western blot analysis of phospho-foxo3a (p-foxo3a), foxo3a, MnSOD, cleaved-caspase-3 (C-caspase-3), and Bcl-xL in the intestine and liver. Results are presented as the mean ± SD, 𝑛=3. **𝑃<0.01 versus sham group; ^#𝑃<0.05 versus I/R group; ^##𝑃<0.01 versus I/R group. 1 indicates Sham; 2, I/R; 3, Sham + PCA (H); 4, I/R + PCA (L); 5, I/R + PCA (H).