Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage

Table 1

PCA pretreatment ameliorated intestinal I/R induced GSH system dysfunction in the intestine and liver.

Group	Intestine GSH; (mg/g protein)	Intestine GSH-PX; (U/g protein)	Liver GSH; (mg/g protein)	Liver GSH-PX; (U/g protein)
Sham	3.71±0.48	87.73±10.51	2.45±0.17	424.31±22.06
I/R	2.25±0.55^∗∗	43.54±8.61^∗∗	1.54±0.09^∗∗	314.16±26.58^∗∗
Sham + PCA (H)	3.81±0.56	94.38±19.45	2.29±0.23	418.56±15.72
I/R + PCA (L)	2.75±0.53	69.85±10.58^##	1.76±0.08	357.01±8.51^##
I/R + PCA (H)	3.23±0.16^##	72.40±11.03^##	2.07±0.17^##	379.42±4.39^##

Results are presented as the mean ± SD, 𝑛=10. **𝑃<0.01 versus sham; ^##𝑃<0.01 versus I/R.