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The Scientific World Journal
Volume 2014, Article ID 391250, 5 pages
Research Article

Helicobacter pylori Infection and Insulin Resistance in Diabetic and Nondiabetic Population

1Clinical Research Development Center, Department of Internal Medicine, Qom University of Medical Sciences, Qom, Iran
2Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran

Received 27 July 2014; Accepted 11 October 2014; Published 23 October 2014

Academic Editor: Tomasz Brzozowski

Copyright © 2014 Jamshid Vafaeimanesh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Helicobacter pylori (HP) is a common worldwide infection with known gastrointestinal and nongastrointestinal complications. One of the gastrointestinal side effects posed for this organism is its role in diabetes and increased insulin resistance. The aim of this study was to evaluate the association between HP and insulin resistance in type 2 diabetic patients and nondiabetics. This cross-sectional study was carried out from May to December 2013 on 211 diabetic patients referred to diabetes clinic of Shahid Beheshti Hospital of Qom and 218 patients without diabetes. HP was evaluated using serology method and insulin resistance was calculated using HOMA-IR. The prevalence of H. pylori infection was 55.8% and 44.2% in diabetics and nondiabetics . The study population was divided into two HP positive and negative groups. Among nondiabetics, insulin resistance degree was and in HP+ and HP− patients, respectively . Oppositely, insulin resistance was significantly higher in diabetic HP+ patients rather than seronegative ones versus , . In diabetic patients, in addition to higher prevalence of HP, it causes a higher degree of insulin resistance.