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The Scientific World Journal
Volume 2014, Article ID 398295, 5 pages
http://dx.doi.org/10.1155/2014/398295
Research Article

Prognostic Implication of Preoperative Behavior Changes in Patients with Primary High-Grade Meningiomas

1Department of Neurosurgery, University Medical Centre Ljubljana (UMC Ljubljana), Zaloska 7, 1000 Ljubljana, Slovenia
2Ethics & Bionics/Nanomedicine, Australian Centre of Excellence in Electromaterials Science, University of Tasmania, 7000 Hobart, Australia

Received 19 August 2013; Accepted 20 November 2013; Published 21 January 2014

Academic Editors: V. Pistoia, B. Schaller, and C. J. Vecht

Copyright © 2014 Andrej Vranic and Frederic Gilbert. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

High-grade meningiomas are rare extra-axial tumors, frequently causing brain invasion and prominent brain edema. Patients harboring high-grade meningiomas occasionally present with behavior changes. Data about frequency and prognostic importance of preoperative behavior changes in patients with high-grade meningiomas is missing. 86 patients with primary high-grade meningiomas were analyzed. Statistical analysis was performed to determine correlation of preoperative behavior changes with tumor location, preoperative brain edema, tumor cleavability, tumor grade, Ki67 proliferation index, and microscopic brain invasion. Survival analysis was performed. 30 (34.9%) patients presented with preoperative behavior changes. These changes were more frequent with male patients ( ) and patients older than 55 years ( ). They correlated with frontal location ( ), tumor size ( ), microscopic brain invasion ( ), and brain edema ( ). Preoperative behavior changes did not correlate with duration of symptoms, tumor cleavability, tumor malignancy grade, and Ki67 proliferation index. They were not significantly related to overall survival or recurrence-free survival of patients with primary high-grade meningiomas. Preoperative behavior changes are frequent in patients harboring primary high-grade meningiomas. They correlate with tumor size, microscopic brain invasion, and brain edema. Preoperative behavior changes do not predict prognosis in patients with primary high-grade meningiomas.