Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia

Figure 1

Schematic diagram of the experimental protocol. Baseline open-field (OF) activity and thermal pain thresholds were measured initially. Then rats were divided into two groups (OB and sham groups, receiving olfactory bulbectomy and sham surgery, resp.). Both groups were further divided into two subgroups for either saline or 8-OH-DPAT injection, which was administrated 30 min before behavioral tests (acute administration) or once daily for consecutive 14 days (chronic administration).