Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia

Figure 2

Behavioral outcome of the OB model for depression and depression-induced hypoalgesia. (a) Body weights. Significant decrease was observed in body weights in the OB group in comparison to the control group over the 14-day postoperation period (𝑛=33--48). (b) Open-field test. Significant higher level of locomotor activity was found in the OB rats than in the control rats (𝑛=33--48). (c) Thermal pain threshold test. The paw withdrawal latency to noxious radiant heat stimuli was significantly prolonged in the OB rats (𝑛=33--48). Data are presented as mean ± SEM.***𝑃<0.001.

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