Neoadjuvant Chemotherapy with FOLFOX4 Regimen to Treat Advanced Gastric Cancer Improves Survival without Increasing Adverse Events: A Retrospective Cohort Study from a Chinese Center
Table 4
Adverse effects associated with preoperative and postoperative chemotherapy.
Adverse events
Neoadjuvant group ()
Adjuvant group ()
value*
Neutropenia: (%)
Grades 1-2
6 (26.1)
7 (20.0)
NS
Grades 3-4
3 (13.0)
3 (8.8)
Nausea and vomiting: (%)
Grades 1-2
4 (17.4)
8 (22.9)
NS
Grades 3-4
1 (4.3)
2 (5.7)
Liver toxicity: (%)
Grades 1-2
1 (4.3)
2 (5.7)
NS
Grades 3-4
0 (0)
0 (0)
Stomatitis: (%)
Grades 1-2
2 (8.7)
1 (2.9)
NS
Grades 3-4
0 (0)
0 (0)
Diarrhea: (%)
Grades 1-2
2 (8.7)
2 (5.7)
NS
Grades 3-4
0 (0)
2 (5.7)
Neurologic effects: (%)
Grades 1-2
4 (17.4)
2 (5.7)
NS
Grades 3-4
0 (0)
0 (0)
Skin effects: (%)
Grades 1-2
1 (4.3)
1 (2.9)
NS
Grades 3-4
0 (0)
0 (0)
Comparisons for categorical variables performed using chi-square test. NS: no significance.
