Research Article
Gastroretentive Pulsatile Release Tablets of Lercanidipine HCl: Development, Statistical Optimization, and In Vitro and In Vivo Evaluation
Table 1
Composition of immediate release core tablets of lercanidipine HCl.
| Batch number | Ingredients (mg) | Total weight (mg) | Drug | MCC | Lactose | PVP K30 | SSG | Cross PVP | Ac-Di-Sol | Magnesium stearate | Talc |
| F 1 | 10.00 | 82.00 | — | 3.00 | — | 3.00 | — | 1.00 | 1.00 | 100 | F 2 | 10.00 | 82.00 | — | 1.00 | 5.00 | — | — | 1.00 | 1.00 | 100 | F 3 | 10.00 | 80.00 | — | 3.00 | 5.00 | — | — | 1.00 | 1.00 | 100 | F 4 | 10.00 | 78.00 | — | 5.00 | 5.00 | — | — | 1.00 | 1.00 | 100 | F 5 | 10.00 | 82.00 | — | 3.00 | 3.00 | — | — | 1.00 | 1.00 | 100 | F 6 | 10.00 | 82.00 | — | 3.00 | — | — | 3.00 | 1.00 | 1.00 | 100 | F 7 | 10.00 | — | 34.00 | 2.50 | 2.50 | — | — | 0.50 | 0.50 | 50 | F 8 | 10.00 | — | 35.25 | 2.50 | 1.25 | — | — | 0.50 | 0.50 | 50 | F 9 | 10.00 | — | 32.75 | 2.50 | 3.75 | — | — | 0.50 | 0.50 | 50 | F 10 | 10.00 | — | 34.00 | 2.50 | — | 2.50 | — | 0.50 | 0.50 | 50 | F 11 | 10.00 | — | 34.00 | 2.50 | — | — | 2.50 | 0.50 | 0.50 | 50 |
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