Gastroretentive Pulsatile Release Tablets of Lercanidipine HCl: Development, Statistical Optimization, and In Vitro and In Vivo Evaluation

Table 2

Composition of coat for floating pulsatile release tablets.

Batch number	Ingredients (mg)						Total weight
	PEO	Lactose	Sodium bicarbonate	Talc	Magnesium stearate	% of PEO
FP 1	60	174	60	3	3	20	300
FP 2	80	232	80	4	4	20	400
FP 3	100	290	100	5	5	20	500
FP 4	90	144	60	3	3	30	300
FP 5	120	192	80	4	4	30	400
FP 6	150	240	100	5	5	30	500
FP 7	120	192	80	4	4	30	400
FP 8	120	192	80	4	4	30	400
FP 9	120	192	80	4	4	30	400
FP 10	120	192	80	4	4	30	400
FP 11	120	114	60	3	3	40	300
FP 12	160	152	80	4	4	40	400
FP 13	200	190	100	5	5	40	500
FP 14	96	278.4	96	4.8	4.8	20	480