Research Article
Gastroretentive Pulsatile Release Tablets of Lercanidipine HCl: Development, Statistical Optimization, and In Vitro and In Vivo Evaluation
Table 2
Composition of coat for floating pulsatile release tablets.
| Batch number | Ingredients (mg) | Total weight | PEO | Lactose | Sodium bicarbonate | Talc | Magnesium stearate | % of PEO |
| FP 1 | 60 | 174 | 60 | 3 | 3 | 20 | 300 | FP 2 | 80 | 232 | 80 | 4 | 4 | 20 | 400 | FP 3 | 100 | 290 | 100 | 5 | 5 | 20 | 500 | FP 4 | 90 | 144 | 60 | 3 | 3 | 30 | 300 | FP 5 | 120 | 192 | 80 | 4 | 4 | 30 | 400 | FP 6 | 150 | 240 | 100 | 5 | 5 | 30 | 500 | FP 7 | 120 | 192 | 80 | 4 | 4 | 30 | 400 | FP 8 | 120 | 192 | 80 | 4 | 4 | 30 | 400 | FP 9 | 120 | 192 | 80 | 4 | 4 | 30 | 400 | FP 10 | 120 | 192 | 80 | 4 | 4 | 30 | 400 | FP 11 | 120 | 114 | 60 | 3 | 3 | 40 | 300 | FP 12 | 160 | 152 | 80 | 4 | 4 | 40 | 400 | FP 13 | 200 | 190 | 100 | 5 | 5 | 40 | 500 | FP 14 | 96 | 278.4 | 96 | 4.8 | 4.8 | 20 | 480 |
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