Gastroretentive Pulsatile Release Tablets of Lercanidipine HCl: Development, Statistical Optimization, and In Vitro and In Vivo Evaluation

Table 7

Pharmacokinetic parameters from the plasma concentration-time curves.

Parameters	Immediate release core tablet (F 7)	Floating pulsatile release tablet (FP 14)
(ng/mL)	168.58 ± 19.25	176.55 ± 22.14
(h)	1.00 ± 0.25	6.00 ±
(ng·h/mL)	2709.62 ± 184.29	3346.55 ± 273.37
(ng·h/mL)	3016.47 ± 206.13	3785.32 ± 228.24
MRT (h)	15.60 ± 1.94	20.1 ± 2.41
(L)	17.01 ± 1.16	13.70 ± 0.82
CL (L/h)	1.35 ± 0.12	1.07 ± 0.09
(h)	8.70 ± 0.52	8.80 ± 0.46
(1/h)	0.079 ± 0.01	0.078 ± 0.01

Significant compared to F 7 at < 0.05. All values are presented as mean ± SEM, = 3.