Biochemical Characterization of Early Osteoarthritis in the Ankle
Table 2
Correlation of intra-articular protein levels with duration of complains, functional scores, and OA-related changes in conventional X-ray or MRI.
Duration of complains
FFI (reverse)
CFSS
AOFAS
KLS
AOSS
MMP-13/MMP-13/TPC
Correlation
—/—
—/—
—/—
—/—
—/—
—/—
Valid cases
49
49
49
49
49
38
Signif. ()
n.s./n.s.
n.s./n.s.
n.s./n.s.
n.s./n.s.
n.s./n.s.
n.s./n.s.
IL-1/IL-1/TPC
Correlation
—/—
—/—
—/—
—/—
—/neg.
—/—
Valid cases
49
49
49
49
49
38
Signif. ()
n.s./n.s.
n.s./n.s.
n.s./n.s.
n.s./n.s.
n.s./0.023
n.s./n.s.
bFGF/bFGF/TPC
Correlation
pos./—
—/—
—/—
—/—
pos./—
—/—
Valid cases
49
49
49
49
49
38
Signif. ()
0.043/n.s.
n.s./n.s.
n.s./n.s.
n.s./n.s.
0.044/n.s.
n.s./n.s.
BMP-2/BMP-2/TPC
Correlation
—/—
pos./pos.
—/—
—/—
—/neg.
—/—
Valid cases
49
49
49
49
49
38
Signif. ()
n.s./n.s.
0.027/0.028
n.s./c
n.s./n.s.
n.s./0.025
n.s./n.s.
BMP-7/BMP-7/TPC
Correlation
pos./—
pos./—
—/—
neg./—
pos./—
—/—
Valid cases
49
49
49
49
49
38
Signif. ()
0.014/n.s.
0.008/n.s.
n.s./n.s.
0.032/n.s.
0.014/—
n.s./n.s.
Endoglin/endoglin/TPC
Correlation
—/—
—/—
pos./—
—/—
—/—
—/—
Valid cases
49
49
49
49
49
38
Signif. ()
n.s./n.s.
n.s./n.s.
0.025/n.s.
n.s./n.s.
n.s./n.s.
n.s./n.s.
IGF-1/IGF-1/TPC
Correlation
—/—
neg./—
pos./—
—/—
—/—
—/—
Valid cases
49
49
49
49
49
38
Signif. ()
n.s./n.s.
0.042/n.s.
0.031/n.s.
n.s./n.s.
n.s./n.s.
n.s./n.s.
IGF-1R/IGF-1R/TPC
Correlation
—/—
—/neg.
—/—
—/—
—/neg.
—/—
Valid cases
49
49
49
49
49
38
Signif. ()
n.s./n.s.
n.s./0.037
n.s./n.s.
n.s./n.s.
n.s./0.010
n.s./n.s.
Aggrecan/aggrecan/TPC
Correlation
pos./pos.
pos./pos.
—/—
neg./neg.
pos./pos.
—/—
Valid cases
49
49
49
49
49
38
Signif. ()
0.004/0.010
0.036/0.022
n.s./n.s.
0.026/0.018
0.001/0.005
n.s./n.s.
Signif. (): value for statistical significance Spearman’s , FFI: foot function index, CFSS: calcaneal fractures scoring system according to Kerr, AOFAS: ankle-hindfoot scale, KLS: Kellgren Lawrence Score, AOSS: ankle osteoarthritis scoring system. Statistical tests refer to correlations to the absolute protein concentrations and the protein concentrations in relation to TPC.
