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The Scientific World Journal
Volume 2014, Article ID 452892, 11 pages
http://dx.doi.org/10.1155/2014/452892
Research Article

Evaluation of the Cytotoxic Effects of CAM Therapies: An In Vitro Study in Normal Kidney Cell Lines

Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat Solan 173234, India

Received 26 August 2013; Accepted 7 November 2013; Published 3 February 2014

Academic Editors: D. Geetha, F. Thaiss, and Y. Uchiyama-Tanaka

Copyright © 2014 Shagun Arora et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “Kidney cancer incidence and mortality worldwide in 2008: Globocan Cancer Fact Sheet,” Globocan 2008, IARC, 2010.
  2. J. N. Yuan, Y. Chao, W. P. Lee et al., “Chemotherapy with etoposide, doxorubicin, cisplatin, 5-fluorouracil, and leucovorin for patients with advanced hepatocellular carcinoma,” Medical Oncology, vol. 25, no. 2, pp. 201–206, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. C.-C. Lin, C. H. Hsu, C. Y. Huang et al., “Weekly cisplatin plus infusional high-dose 5-fluorouracil and leucovorin (P-HDFL) for metastatic urothelial carcinoma: an effective regimen with low toxicity,” Cancer, vol. 106, no. 6, pp. 1269–1275, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. H. I. El-Sayyad, M. F. Ismail, F. M. Shalaby et al., “Histopathological effects of cisplatin, doxorubicin and 5-flurouracil (5-FU) on the liver of male albino rats,” International Journal of Biological Sciences, vol. 5, no. 5, pp. 466–473, 2009. View at Google Scholar · View at Scopus
  5. L. Gao, R. Ma, J. Zhou, and S. Cheng, “Changes of serum erythropoietin during cisplatin- or 5-fluorouracil-induced anemia in rats,” Toxicology Mechanisms and Methods, vol. 16, no. 9, pp. 501–506, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Skretkowicz, M. Sekulska, M. Danilewicz, M. Wagrowska-Danilewicz, and P. Polakowski, “Effect of some anticancer drugs and combined chemotherapy on renal toxicity,” Biological Signals, vol. 5, no. 1, pp. 51–58, 1996. View at Google Scholar · View at Scopus
  7. G. Bodeker and F. Kronenberg, “A public health agenda for traditional, complementary, and alternative medicine,” The American Journal of Public Health, vol. 92, no. 10, pp. 1582–1591, 2002. View at Google Scholar · View at Scopus
  8. A. Broom, K. R. Nayar, P. Tovey et al., “Indian cancer patients’ use of Traditional, Complementary and Alternative Medicine (TCAM) and delays in presentation to hospital,” Oman Medical Journal, vol. 24, no. 2, pp. 99–102, 2009. View at Publisher · View at Google Scholar
  9. R. M. Bell, “A review of complementary and alternative medicine practices among cancer survivors,” Clinical Journal of Oncology Nursing, vol. 14, no. 3, pp. 365–370, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. H. Liu, M. L. Li, M. Y. Hsu et al., “Effects of a chinese herbal medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on renal cancer cell growth and metastasis,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 935860, 10 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. WHO, Diet, Nutrition and the Prevention of Chronic Diseases, Technical Report Series, no. 916, World Health Organization, Geneva, Switzerland, 2003.
  12. P. Chaturvedi, U. Chaturvedi, and B. Sanyal, “Alternative medicine and cancer patients in less developed countries,” The Lancet Oncology, vol. 3, no. 1, p. 10, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. S. K. Pai, “Use of alternative cancer medicine in India,” The Lancet Oncology, vol. 3, no. 7, pp. 394–395, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Rana, J. K. Kamboj, and V. Gandhi, “Living life the natural way—wheatgrass and health,” Functional Foods in Health and Disease, vol. 1, no. 11, pp. 444–456, 2011. View at Google Scholar
  15. A. Dey, “Achyranthes aspera L: phytochemical and pharmacological aspects,” International Journal of Pharmaceutical Sciences Review and Research, vol. 9, no. 2, pp. 72–82, 2011. View at Google Scholar · View at Scopus
  16. G. H. Beulah, A. A. Margret, and J. Nelson, “Marvelous medicinal mushrooms,” International Journal of Pharma and Bio Sciences, vol. 3, no. 1, pp. 611–6115, 2013. View at Google Scholar
  17. J. Asgarpanah and R. Khoshkam, “Phytochemistry and pharmacological properties of Ruta graveolens L.,” Journal of Medicinal Plants Research, vol. 6, no. 23, pp. 3942–3949, 2012. View at Google Scholar
  18. C. N. Lai, “Chlorophyll: the active factor in wheat sprout extracts inhibiting the metabolic activation of carcinogens in vitro,” Nutrition and Cancer, vol. 1, pp. 19–21, 1979. View at Google Scholar
  19. C. N. Lai, B. J. Dabney, and C. R. Shaw, “Inhibition of in vitro metabolic activation of carcinogens by wheat sprout extracts,” Nutrition and Cancer, vol. 1, pp. 27–30, 1978. View at Google Scholar
  20. G. Falcioni, D. Fedeli, L. Tiano et al., “Antioxidant activity of wheat sprouts extract in vitro: inhibition of DNA oxidative damage,” Journal of Food Science, vol. 67, no. 8, pp. 2918–2922, 2002. View at Google Scholar · View at Scopus
  21. J. W. Fahey, K. K. Stephenson, A. T. Dinkova-Kostova, P. A. Egner, T. W. Kensler, and P. Talalay, “Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes,” Carcinogenesis, vol. 26, no. 7, pp. 1247–1255, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Peryt, T. Szymczyk, and P. Lesca, “Mechanism of antimutagenicity of wheat sprout extracts,” Mutation Research, vol. 269, no. 2, pp. 201–215, 1992. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Padalia, S. Drabu, I. Raheja, A. Gupta, and M. Dhamija, “Multitude potential of wheatgrass juice (Green Blood),” An Overview, Chronicles of Young Scientists, vol. 1, no. 2, pp. 23–228, 2010. View at Google Scholar
  24. S. Edwin, E. E. Jarald, L. Deb et al., “Wound healing and antioxidant activity of Achyranthes aspera,” Pharmaceutical Biology, vol. 46, no. 12, pp. 824–828, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Y. Vasudeva, G. R. Duddukuri, B. G. Sunil, and R. R. Athota, “Immunomodulatory activity of Achyranthes aspera on the elicitation of antigen-specific murine antibody response,” Pharmaceutical Biology, vol. 40, no. 3, pp. 175–178, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. I. C. F. R. Ferreira, L. Barros, and R. M. V. Abreu, “Antioxidants in wild mushrooms,” Current Medicinal Chemistry, vol. 16, no. 12, pp. 1543–1560, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. P. H. K. Ngai and T. B. Ng, “A mushroom (Ganoderma capense) lectin with spectacular thermostability, potent mitogenic activity on splenocytes, and antiproliferative activity toward tumor cells,” Biochemical and Biophysical Research Communications, vol. 314, no. 4, pp. 988–993, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Pathak, A. S. Multani, P. Banerji, and P. Banerji, “Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: a novel treatment for human brain cancer,” International Journal of Oncology, vol. 23, no. 4, pp. 975–982, 2003. View at Google Scholar · View at Scopus
  29. M. Ratheesh and A. Helen, “Anti-inflammatory activity of Ruta graveolens Linn on carrageenan induced paw edema in wistar male rats,” African Journal of Biotechnology, vol. 6, no. 10, pp. 1209–1211, 2007. View at Google Scholar · View at Scopus
  30. S. Tandon, A. Arora, S. Singh, J. Monga, and S. Arora, “Antioxidant profiling of Triticum aestivum (wheatgrass) and its antiproliferative activity in MCF-7 breast cancer cell line,” Journal of Pharmacy Research, vol. 4, no. 12, pp. 4601–4604, 2011. View at Google Scholar
  31. S. Arora, S. Goyal, J. Balani, and S. Tandon, “Enhanced antiproliferative effects of aqueous extracts of some medicinal mushrooms on colon cancer cells,” International Journal of Medicinal Mushrooms, vol. 15, no. 3, pp. 301–314, 2013. View at Google Scholar
  32. S. Arora, A. Aggarwal, P. Singhla, S. Jyoti, and S. Tandon, “Antiproliferative effects of homeopathic drugs on human kidney, colon and breast cancer cells,” Homeopathy, vol. 102, pp. 274–282, 2013. View at Google Scholar
  33. S. D. Kulkarni, J. C. Tilak, R. Acharya, N. S. Rajurkar, T. P. A. Devasagayam, and A. V. R. Reddy, “Evaluation of the antioxidant activity of wheatgrass (Triticum aestivum L.) as a function of growth under different conditions,” Phytotherapy Research, vol. 20, no. 3, pp. 218–227, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. M. H. Roudkenar, R. Halabian, A. M. Roushandeh et al., “Lipocalin 2 regulation by thermal stresses: protective role of Lcn2/NGAL against cold and heat stresses,” Experimental Cell Research, vol. 315, no. 18, pp. 3140–3151, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Phromnoi, S. Reuter, B. Sung, P. Limtrakul, and B. B. Aggarwal, “A dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways,” Anticancer Research, vol. 30, no. 9, pp. 3599–3610, 2010. View at Google Scholar · View at Scopus
  36. D. Ribble, N. B. Goldstein, D. A. Norris, and Y. G. Shellman, “A simple technique for quantifying apoptosis in 96-well plates,” BMC Biotechnology, vol. 5, article 12, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Bossù, “Qualitative analysis of DNA fragmentation by agarose gel electrophoresis,” http://www.cyto.purdue.edu/archive/flowcyt/research/cytotech/apopto/data/chap4.htm.
  38. R. Han, Y. M. Yang, J. Dietrich, A. Luebke, M. Mayer-Pröschel, and M. Noble, “Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system,” Journal of Biology, vol. 7, no. 4, p. 12, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. E. Nora and H. M. Ali, “Protective effect of captopril against 5-fluorouracil-induced hepato and nephrotoxicity in male albino rats,” Journal of American Science, vol. 8, no. 2, 2012. View at Google Scholar