The Scientific World Journal
Volume 2014, Article ID 472373, 10 pages
http://dx.doi.org/10.1155/2014/472373
#Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1
Department of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
Received 2 November 2014; Accepted 5 December 2014; Published 31 December 2014
Academic Editor: Georgiy B. Shul’pin
Copyright © 2014 Dalya Al-Saad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Influenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with the in vitro antiviral tests. The nucleoside derivatives were tested for their inhibitory activity against a variety of viruses. Promising antiviral activities were found for specific compounds in the case of flu A H1N1.