#Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1

Table 1

Primary antiviral activities of compounds 13a–d and 14a–d against influenza A H1N1 virus.

Entry	Compounds	EC50		SI50
1		>100	>100	0
2		>100	>100	0
3		>100	>100	0
4		>100	>100	0
5		>100	>100	0
6		>100	>100	0
7		>100	>100	0
8		>100	>100	0
9		>100	>100	0
10		>100	>100	0
11		>100	>100	0
12		>100	>100	0
13		>100	>100	0
14		>100	>100	0
15		37	>100	>2.7
16		54	74	1.4
17	Ribavirin	3.2	>100	>31
18	Ribavirin	3.1	42	14

[a] Control assay: visual (cytopathic effect/toxicity). [b] Control assay: neutral red (cytopathic effect/toxicity). [c] Drug control range 0.1–100 g/mL; ribavirin control concentration range 0.1–100 g/mL.