The Scientific World Journal

Research Article

Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method

Table 1

Amino acid residues at the ligand binding sites of BACE1 and BACE2. The amino acid residue numbering is according to their respective 3D structure (1FNK and 2EWY).
BACE1BACE2
Amino acid residuesTrace statusAmino acid residuesTrace status
Ser10Conserved**—
Gly11Conserved**—
Gln12Conserved**—
Gly13Conserved**—
Leu 30ConservedLeu46Conserved
Asp32ConservedAsp48Conserved
GLy34ConservedGly50Conserved
Ser35ConservedSer51Conserved
Val69ConservedVal85Conserved
Pro70Group-specificLys86Group-specific
Tyr71ConservedTyr87Conserved
Thr72ConservedThr88Conserved
Gln73ConservedGln89Conserved
*—Gln90Conserved
Phe108ConservedPhe124Conserved
Ile110Group-specificLeu126Group-specific
Trp115ConservedTrp131Conserved
Ile118ConservedIle134Conserved
Ile126Group-specificLeu142Group-specific
Tyr198ConservedTyr211Conserved
Lys224Conserved**—
Ile226ConservedIle239Conserved
ASP228ConservedAsp241Conserved
Gly230ConservedGly243Conserved
Thr231ConservedThr244Conserved
Thr232ConservedThr245Conserved
Asn233Group-specificLeu246Group-specific
Arg235ConservedArg248Conserved
Thr329Conserved**—
*—Ser337Conserved
*Ligand binding site not identified in BACE1.
**Ligand binding site not identified in BACE2.