The Scientific World Journal

Clinical Study

Tinzaparin Provides Lower Lipid Profiles in Maintenance Hemodialysis Patients: A Cross-Sectional Observational Study

Table 2

The linear regression mode for evaluating the relationship between independent variables and lipid profile in HD patients.


Variables	Triglyceride				Total cholesterol
	Crude		Multivariable Forward stepwise regression		Crude		Multivariable Forward stepwise repression
	(CI 95%)¹	value	(CI 95%)	value	(CI 95%)	value	(CI 95%)	value

Tinzaparin use	−39.9 (−76.7, −3.0)	0.034	−40.8 (−75.1, −6.5)	0.020	−9.3 (−21.6, 3.0)	0.138	−13.0 (−24.5, −1.56)	0.026
Sex (male)	−13.1 (−36.3, 10.0)	0.265	−26.8 (−48.1, −5.4)	0.014	−12.8 (−20.4, −5.1)	0.001	−19.1 (−26.5, −11.8)	<0.001
Age (per year)	−0.52 (−1.40, 0.35)	0.240			−0.32 (−0.61, −0.02)	0.032
Diabetes	35.1 (11.7, 58.5)	0.003			−11.6 (−19.4, −3.8)	0.004	−12.0 (−20.0, −4.0)	0.003
BMI (per kg/m²)	8.51 (5.51, 11.5)	<0.001	6.33 (3.36, 9.31)	<0.001	−0.12 (−1.16, 0.91)	0.819
SBP (per mmHg)	0.47 (0.02, 0.91)	0.039	0.54 (0.12, 0.96)	0.012	0.03 (−1.11, 0.18)	0.680
DBP (per mmHg)	0.05 (−0.13, 0.23)	0.576			−0.03 (−0.10, 0.02)	0.213
Lipid-lowering agent	36.5 (4.81, 68.3)	0.024			−1.8 (−12.5, 8.7)	0.729
HD vintage (per month)	−0.35 (−0.52, −0.18)	<0.001	−0.18 (−0.34, −0.01)	0.029	−0.03 (−0.09, 0.02)	0.240	−0.78 (−0.13, −0.01)	0.010
AK (versus polysulfone)
PMMA	17.4 (−8.9, 43.9)	0.195			−0.93 (−9.79, 7.93)	0.837
Cellulose citrate	−5.3 (−43.9, 33.2)	0.786			8.16 (−4.74, 21.0)	0.215
KT/V (per unit)	−87.4 (−149.7, −25.1)	0.006			−1.71 (−22.7, 19.3)	0.873
Albumin (per g/dL)	26.5 (−4.52, 57.5)	0.094			33.5 (23.6, 43.5)	<0.001	27.6 (17.2, 38.0)	<0.001
AST (per IU/L)	0.23 (−0.26, 0.73)	0.359			−0.09 (−0.26, 0.07)	0.257
ALT (per IU/L)	0.21 (−0.16, 0.58)	0.261			−0.02 (−0.15, 0.09)	0.678
Hemoglobin (per g/dL)	8.37 (−0.87, 17.6)	0.076			6.30 (3.25, 9.34)	<0.001	5.0 (1.98, 8.04)	0.001
T-bilirubin (per mg/dL)	−23.5 (−69.6, 22.5)	0.315			−16.0 (−31.4, −0.72)	0.040
Ferritin (per μg/dL)	0.006 (−0.01, 0.03)	0.651			−0.004 (−0.012, 0.005)	0.373
Iron (per g/dL)	0.329 (−0.16, 0.82)	0.190			0.28 (0.11, 0.44)	0.001
TIBC (per g/dL)	0.86 (0.59, 1.12)	<0.001	0.70 (0.44, 0.97)	<0.001	0.21 (0.11, 0.30)	<0.001	0.10 (0.01, 0.19)	0.028
iPTH (per pg/mL)	−0.05 (−0.08, −0.01)	0.008			0.005 (−0.008, 0.018)	0.445
Alk-p (per mg/dL)	−0.11 (−0.27, 0.05)	0.181			−0.007 (−0.06, 0.04)	0.788
Sodium (per meq/L)	−4.62 (−8.18, −1.05)	0.011	−3.77 (−7.04, −0.50)	0.024	0.27 (−0.92, 1.47)	0.650
Potassium (per meq/L)	−6.05 (−23.5, 11.0)	0.496			7.54 (1.74, 13.3)	0.011
iCa (per mg/dL)	−0.50 (−22.6, 21.6)	0.965			2.18 (−5.21, 9.58)	0.562
Phosphate (per mg/dL)	−3.36 (−11.8, 5.12)	0.436	−14.0 (22.4, −5.6)	0.001	3.15 (0.32, 5.98)	0.029
Uric acid (per mg/dL)	17.9 (9.39, 26.5)	<0.001	16.2 (7.6, 24.8)	<0.001	4.85 (1.96, 7.75)	0.001

β is the regression coefficient. Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure, HD, hemodialysis; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TIBC, total iron-binding capacity; iPTH, intact parathyroid hormone; Alk-p, alkaline phosphatase.