Tinzaparin Provides Lower Lipid Profiles in Maintenance Hemodialysis Patients: A Cross-Sectional Observational Study

Table 3

The linear regression mode for evaluating the relationship between independent variables and lipid profile in HD patients.

Variables	LDL				HDL
	Crude		Multivariable; Forward stepwise regression		Crude		Multivariable; Forward stepwise regression
	β (CI 95%)^1	value	(CI 95%)	value	(CI 95%)^1	value	(CI 95%)	value
Tinzaparin use	−6.21 (−16.9, 4.5)	0.256			4.8 (−0.9, 10.5)	0.099
Sex (male)	−2.0 (−8.8, 4.6)	0.543	−6.80 (−13.2, −0.39)	0.038	−7.9 (−11.4, −4.3)	<0.001	−5.84 (−9.29, −2.32)	0.001
Age (per year)	−0.26 (−0.51, −0.005)	0.046			−0.32 (−0.16, 0.10)	0.649
Diabetes	−6.7 (−13.5, 0.11)	0.054			−11.3 (−14.8, −7.8)	<0.001	−5.46 (−8.89, −2.03)	0.002
BMI (per kg/m^2)	0.15 (−0.74, 1.06)	0.731			−1.66 (−2.12, −1.21)	<0.001	−1.47 (−1.92, −1.02)	<0.001
SBP (per mmHg)	−0.007 (−0.13, 0.12)	0.917			−0.04 (−0.11, 0.03)	0.260
DBP (per mmHg)	−0.03 (−0.08, 0.02)	0.255			−0.01 (−0.04, 0.01)	0.195
Lipid-lowering agent	−10.3 (−19.5, −1.1)	0.028	−12.1 (−20.8, −3.43)	0.006	−0.26 (−5.22, 4.69)	0.917
HD vintage (per month)	−0.04 (−0.09, 0.003)	0.064			0.06 (0.03, 0.09)	<0.001
AK (versus polysulfone)
PMMA	−6.01 (−10.0, −1.93)	0.004	2.96 (−4.29, 10.2)	0.423	−0.84 (−8.53, 6.83)	0.828
Cellulose citrate	−1.22 (−7.16, 4.72)	0.686	12.39 (1.85, 22.94)	0.021	9.43 (−1.75, 20.6)	0.098
KT/V	−12.0 (−30.2, 6.1)	0.194			24.1 (14.6, 33.6)	<0.001	11.4 (1.45, 21.4)	0.025
Albumin (per g/dL)	26.5 (17.8, 35.2)	<0.001	23.7 (14.9, 32.6)	<0.001	8.9 (4.2, 13.7)	<0.001	10.4 (6.10, 14.71)	<0.001
AST (per IU/L)	−0.29 (−0.43, −0.14)	<0.001	−0.27 (−0.41, −0.13)	<0.001	−0.1 (−0.18, −0.03)	0.005
ALT (per IU/L)	−0.16 (−0.27, −0.05)	0.002			−0.08 (−0.13, −0.02)	0.006
Hemoglobin (per g/dL)	4.67 (2.01, 7.32)	0.001			1.04 (−0.39, 2.48)	0.153
T-bilirubin (per mg/dL)	−22.6 (−35.9, −9.43)	0.001			−8.59 (−15.7, −1.47)	0.018
Ferritin (per μg/dL)	−0.01 (−0.01, −0.003)	0.006			−0.006 (−0.009, −0.002)	0.004	−0.007 (−0.010, −0.003)	<0.001
Iron (per μg/dL)	0.21 (0.07, 0.35)	0.003	0.18 (0.04, 0.32)	0.009	0.03 (−0.046, 0.107)	0.431
TIBC (per μg/dL)	0.09 (0.011, 0.172)	0.025			−0.008 (−0.05, 0.03)	0.704
iPTH (per pg/mL)	<0.001 (−0.01, 0.01)	0.987			0.01 (0.007, 0.019)	<0.001	0.008 (0.002, 0.013)	0.006
Alk-p (per mg/dL)	−0.03 (−0.08, 0.01)	0.164			0.02 (−0.003, 0.047)	0.085
Sodium (per meq/L)	0.83 (−0.20, 1.87)	0.114			0.26 (−0.28, 0.82)	0.344
Potassium (per meq/L)	5.78 (0.73, 10.8)	0.025			3.82 (1.13, 6.51)	0.005
iCa (per mg/dL)	−3.16 (−9.58, 3.25)	0.333			5.38 (1.99, 8.78)	0.002
Phosphate (per mg/dL)	2.29 (−0.16, 4.75)	0.068			1.61 (0.30, 2.92)	0.016
Uric acid (per mg/dL)	2.6 (0.07, 5.13)	0.044			−0.67 (−2.03, 0,67)	0.326

β is the regression coefficient. Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure, HD, hemodialysis; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TIBC, total iron-binding capacity; iPTH, intact parathyroid hormone; Alk-p, alkaline phosphatase.