Syntheses of Isoxazoline-Carbocyclic Nucleosides and Their Antiviral Evaluation: A Standard Protocol

Table 1

Tautomeric ratios and chemical shifts for compounds 14a,bS.

Solvent	I/II	CH=N	Ha	Hb	Hc	Hd	He
CD3COCD3	1/1.5	(I) 8.23, 8.44	4.61	5.73	4.49	5.18	2.59
		(II) 8.78, 8.83	4.64	5.81	4.54	5.31	2.65
DMSO-d6	4/1	(I) 8.14, 8.43	4.30	5.62	4.26	5.00	2.38
		(II) 8.80, 8.81	4.30	5.74	4.26	5.19	2.45
CD3OD	1/1	(I) 8.15, 8.50	4.90	5.60	4.45	5.16	2.45
		(II) 8.78, 8.82	4.90	5.75	4.40	5.27	2.45
CD3COCD3	2/1	(I) 8.25, 8.34	4.62	5.75	4.45	5.15	2.50
		(II) 8.75, 8.78	4.62	5.76	4.50	5.25	2.58
DMSO-d6	1/1	(I) 8.84, 8.87	4.34	5.71	4.34	5.11	2.41
		(II) 8.24, 8.48	4.34	5.61	4.34	5.95	2.32
CD3OD	1/1.5	(I) 8.81, 8.85	4.48	5.76	4.48	5.29	2.50
		(II) 8.18, 8.50	4.48	5.67	4.48	5.16	2.50