Manipulating Ratio Spectra for the Spectrophotometric Analysis of Diclofenac Sodium and Pantoprazole Sodium in Laboratory Mixtures and Tablet Formulation
Table 4
Determination of diclofenac and pantoprazole in DUFEX tablets by the proposed methods and the application of standard addition technique.
Claimed (mg)
Analysis of DUFEX tablets
Standard addition
% Recoverya (% mean ± SD)
Taken (μg/mL)
Added (μg/mL)
% Recoverya (% mean ± SD)
RPP
1DD
MCR
RPP
1DD
MCR
Diclofenac
75
99.71 ± 1.04
100.60 ± 0.83
99.65 ± 1.04
7.5
6.0
100.16 ± 0.64
100.17 ± 1.28
99.68 ± 1.23
7.5
7.5
100.23 ± 1.19
98.97 ± 0.83
99.25 ± 0.68
7.5
8.0
99.75 ± 0.86
100.35 ± 0.86
99.84 ± 0.99
Mean
100.05
99.83
99.59
SD
0.899
0.990
0.968
Pantoprazole
20
100.64 ± 0.57
100.35 ± 0.77
99.79 ± 0.89
2.0
1.6
100.81 ± 0.84
100.55 ± 1.21
99.22 ± 1.12
2.0
2.0
100.21 ± 0.58
100.39 ± 0.83
99.45 ± 1.18
2.0
2.4
99.48 ± 0.87
99.37 ± 0.84
100.40 ± 0.94
Mean
100.17
100.10
99.69
SD
0.767
0.960
1.078
Mean of three replicate measurements; RPP: ratio spectra peak to peak measurement method; 1DD: ratio derivative method; MCR: mean centering of ratio spectra method; SD: standard deviation.
