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The Scientific World Journal
Volume 2014, Article ID 507197, 10 pages
Research Article

Ameliorative Potential of Tamarindus indica on High Fat Diet Induced Nonalcoholic Fatty Liver Disease in Rats

1College of Veterinary and Animal Sciences, Mannuthy, Thrissur 680 651, India
2R&D Centre, Natural Remedies, Plot No.5B, VeerasandraIndl. Area, 19th K.M. Stone, Hosur road, Electronic city, Bangalore, Karnataka 560 100, India

Received 24 August 2013; Accepted 16 December 2013; Published 4 February 2014

Academic Editors: K. M. Botham and M. Enjoji

Copyright © 2014 Suja Rani Sasidharan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nonalcoholic fatty liver disease (NAFLD), the prevalence of which is rising globally with current upsurge in obesity, is one of the most frequent causes of chronic liver diseases. The present study evaluated the ameliorative effect of extract of Tamarindus indica seed coat (ETS) on high fat diet (HFD) induced NAFLD, after daily administration at 45, 90, and 180 mg/kg body weight dose levels for a period of 6 weeks, in albino Wistar rats. Treatment with ETS at all tested dose levels significantly attenuated the pathological alterations associated with HFD induced NAFLD viz. hepatomegaly, elevated hepatic lipid and lipid peroxides, serum alanine aminotransferase, and free fatty acid levels as well as micro-/macrohepatic steatosis. Moreover, extract treatment markedly reduced body weight and adiposity along with an improvement in insulin resistance index. The study findings, therefore suggested the therapeutic potential of ETS against NAFLD, acting in part through antiobesity, insulin sensitizing, and antioxidant mechanisms.