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The Scientific World Journal
Volume 2014, Article ID 514942, 4 pages
Research Article

Vascular Closure Devices after Endovascular Procedures in Swine: A Reliable Method?

1Department of Diagnostic and Interventional Radiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
2Department of Radiology, Nara Medical University, 840 Shijo-cho, Kashihra 634-8522, Japan
3Institute of Animal Research, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
4Department of Diagnostic and Interventional Radiology, Philipps-University, Baldingerstrasse, 35043 Marburg, Germany

Received 3 December 2013; Accepted 21 January 2014; Published 11 March 2014

Academic Editors: W. S. Aronow and B. F. Uretsky

Copyright © 2014 P. Isfort et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To investigate the safety and feasibility of the use of a vascular closure device (VCD) after endovascular procedures in swine. Material and Methods. In a study on endovascular therapy, VCD (StarClose, Abbott Vascular, Il, USA) was used in 20 female swines to achieve immediate hemostasis after percutaneous right femoral artery (FA) access. 10 animals were sacrificed immediately after the study and 10 animals were sacrificed 28 days after the initial study. To ensure complete hemostasis and patency of the femoral artery, a CT-angiography of the puncture site was performed on day 1 (acute and chronic group) and day 28 (chronic group). After the sacrifice, the femoral artery was explanted and examined macroscopically for signs of VCD dysfunction. Results. Technical success rate was 100% with immediate hemostasis being achieved in all animals. No animals showed evidence of hematoma. During explantation, only small traces of coagulated blood were found in the acute group, while there were no signs of hematoma in the chronic group. CT-angiography immediately after VCD application as well as before sacrifice (chronic group) showed patency of the FA in all cases. Conclusion. The use of VCD to achieve hemostasis after endovascular studies in swine is feasible and safe.