The Scientific World Journal / 2014 / Article / Tab 1 / Review Article
Heat Shock Protein 70 Gene Polymorphisms and Cancer Risk: A Meta-Analysis Table 1 Characteristics of studies included in the meta-analysis.
Study Year Country Ethnicity Cancer type Source of Genotype Genotype (case/control) HWE Total WT Ho Ht VR Ho (
value) HSP70-2 AA AG GG
Chouchane et al. [11 ] 1997a Tunisia African Non-Hodgkin’s lymphoma PB AFLP 44/106 4/22 28/82 12/2 0 Chouchane et al. [11 ] 1997b Tunisia African Breast PB AFLP 40/106 4/22 26/82 10/2 0 Ferrer-Ferrer et al. [12 ] 2013 Costa Rica Mixed Gastric HB RFLP 39/79 7/30 26/32 6/17 0.137 Jalbout et al. [14 ] 2003 Tunisia African Nasopharyngeal PB AFLP 140/274 40/101 68/138 32/35 0.251 Jeng et al. [15 ] 2008 Taiwan (China) Asian Hepatocellular HB AFLP 150/150 28/70 55/65 67/15 0.987
Kádár et al. [16 ] 2008 Hungary European Multiple myeloma PB PCR-RFLP 94/141 34/65 60/76* NA Li et al. [17 ] 2010 China Asian Hepatocellular HB PCR 145/127 48/56 71/62 26/9 0.139 Medhi et al. [18 ] 2013 India Asian Hepatocellular PB PCR-RFLP 185/200 111/156 59/40 15/4 0.453 Mestiri et al. [19 ] 2001 Tunisia African Breast PB PCR 243/174 52/35 123/130 68/9 0 Rehman et al. [20 ] 2009 India Aisian Kangri cancer PB PCR-RFLP 118/95 10/24 103/70 5/1 0 Shibata et al. [23 ] 2009 Japan Asian Gastric HB PCR-RFLP 225/200 46/33 173/155 6/12 0 Srivastava et al. [24 ] 2012 India Asian Pancreatic PB PCR-RFLP 50/50 13/33 29/15 8/2 0.858 Tóth et al. [25 ] 2007 Hungary European Colorectal PB PCR-RFLP 183/141 69/65 87/57 27/19 0.258 Ucisik-Akkaya et al. [26 ] 2010a UK European Childhood ALL PB PCR-RFLP 114/414 58/139 47/199 9/76 0.747 Ucisik-Akkaya et al. [26 ] 2010b Mexico Mixed Childhood ALL PB PCR-RFLP 92/235 27/61 51/111 14/63 0.397 Wang et al. [27 ] 2010 China Asian Lung HB PCR-RFLP 159/202 57/56 72/100 30/46 0.915 Zagouri et al. [28 ] 2012 Greece European Breast HB PCR 113/124 24/32 82/76 7/16 0.006 HSP70-hom TT TC CC Chouchane et al. [11 ] 1997a Tunisia African Non-Hodgkin’s lymphoma PB AFLP 44/106 31/98 10/8 3/0 0.686 Chouchane et al. [11 ] 1997b Tunisia African Breast PB AFLP 40/106 31/98 8/8 1/0 0.686 Ferrer-Ferrer et al. [12 ] 2013 Costa Rica Mixed Gastric HB RFLP 39/79 34/55 5/23 0/1 0.409 Guo et al. [13 ] 2011 China Asian Lung PB TaqMan 1152/1152 674/695 412/411 66/46 0.124 Medhi et al. [18 ] 2013 India Asian Hepatocellular PB PCR-RFLP 185/200 178/144 7/42 0/14 0.0001 Rehman et al. [20 ] 2009 India Aisian Kangri cancer PB PCR-RFLP 118/95 60/28 56/60 2/7 0.001 Sfar et al. [22 ] 2010 Tunisia African Prostate PB PCR-RFLP 101/105 77/65 20/32 4/8 0.164 Ucisik-Akkaya et al. [26 ] 2010a UK European Childhood ALL PB TaqMan 105/371 67/246 30/103 8/22 0.015 Ucisik-Akkaya et al. [26 ] 2010b Mexico Mixed Childhood ALL PB TaqMan 99/245 87/214 11/27 1/4 0.008 Wang et al. [27 ] 2010 China Asian Lung HB PCR-RFLP 159/202 95/141 56/59 8/2 0.120 HSP70-1 GG GC CC Guo et al. [13 ] 2011 China Asian Lung PB TaqMan 1152/1152 589/564 457/486 106/102 0.853 Partida-Rodríguez et al. [21 ] 2010 Mexico Mixed Gastric HB PCR-RFLP 42/106 4/59 37/41 1/6 0.746 Ucisik-Akkaya et al. [26 ] 2010a UK European Childhood ALL PB TaqMan 106/365 47/137 45/162 14/66 0.139 Ucisik-Akkaya et al. [26 ] 2010b Mexico Mixed Childhood ALL PB TaqMan 99/250 62/127 32/98 5/25 0.347 Wang et al. [27 ] 2010 China Asian Lung HB PCR-RFLP 159/202 57/104 65/82 37/16 0.977
HWE, Hardy-Weinberg equilibrium;
was calculated by goodness-of fit
-test,
was considered statistically significant; NA, not available. Ht, heterozygote; VR Ho, variant homozygote; WT Ho, wide-type homozygote; *Numbers of Ht + VR Ho.
