The Scientific World Journal / 2014 / Article / Tab 1

Review Article

Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis

Table 1

Main characteristics of eligible studies.

Author, yearLocation,
and number of centers
Publication
type
Diagnostic criteriaNumber of patientsDose of
acotiamide
Duration of
treatment
Jadad
score

Kusunoki et al.
2012 [11]
Japan, 1 siteFull textRome II criteria42100 mg, tid14–18 d4
Matsueda et al.
2010 (A) [16]
Japan, 33 sitesFull textRome II criteria323100 mg
or 300 mg, tid
4 w5
Matsueda et al.
2010 (B) [16]
Japan, 46 sitesFull textRome II criteria46250 mg, 100 mg
or 300 mg, tid
4 w5
Tack et al.
2009 [17]
Europe, 8 sitesFull textRome II criteria7150 mg, 100 mg
or 300 mg, tid
3 w4
Talley et al.
2008 [18]
USA, 59 sitesMeeting
abstract
Rome II criteria416300 mg, 600 mg
or 900 mg, tid
12 w3
Matsueda et al.
2005 [24]
Japan, NRMeeting
abstract
Patients with FD symptoms and negative endoscopy12750 mg, 100 mg
or 300 mg, tid
4 w2
Matsueda et al.
2012 [25]
Japan, 67 sitesFull textRome III criteria897100 mg, tid4 w5

FD, functional dyspepsia; NR, not reported; RCT, randomized controlled trial; and tid, three times daily.