The Scientific World Journal / 2014 / Article / Tab 2 / Review Article
Efficacy and Safety of Acotiamide for the Treatment of Functional Dyspepsia: Systematic Review and Meta-Analysis Table 2 Pooled RR of acotiamide versus placebo for elimination of FD symptoms by Mantel-Haenszel fixed-effect model.
Groups and subgroups Number of trials [reference] Number of patients RR; 95% CI value
Test of heterogeneity valuePDS 2 [16 ] 396 1.29; 1.09–1.53 0.003 0.830 0% 50 mg, tid 1 [16 ] 151 1.08; 0.76–1.53 0.660 NA NA 100 mg, tid 2 [16 ] 206 1.41; 1.07–1.85 0.010 0.860 0% 300 mg, tid 2 [16 ] 218 1.33; 1.01–1.75 0.040 0.960 0% EPS 2 [16 ] 320 0.92; 0.76–1.11 0.390 0.970 0% 50 mg, tid 1 [16 ] 73 0.88; 0.58–1.34 0.550 NA NA 100 mg, tid 2 [16 ] 184 0.96; 0.72–1.29 0.800 0.520 0% 300 mg, tid 2 [16 ] 192 0.90; 0.67–1.21 0.480 0.990 0% Postprandial fullnessa 3 [16 , 25 ] 1438 1.90; 1.37–2.64 <0.001 0.030 60% 50 mg, tid 1 [16 ] 149 3.19; 1.36–7.44 0.007 NA NA 100 mg, tid 3 [16 , 25 ] 1190 1.75; 1.14–2.66 0.010 0.060 64% 300 mg, tid 2 [16 ] 337 2.05; 0.79–5.34 0.140 0.040 77% Upper abdominal bloating 3 [16 , 25 ] 1232 1.30; 1.12–1.50 <0.001 0.930 0% 50 mg, tid 1 [16 ] 135 1.26; 0.79–2.01 0.330 NA NA 100 mg, tid 3 [16 , 25 ] 1001 1.29; 1.08–1.54 0.005 0.550 0% 300 mg, tid 2 [16 ] 310 1.34; 0.99–1.80 0.060 0.730 0% Early satiety 3 [16 , 25 ] 1206 1.39; 1.19–1.61 <0.001 0.830 0% 50 mg, tid 1 [16 ] 133 1.60; 0.95–2.70 0.080 NA NA 100 mg, tid 3 [16 , 25 ] 1002 1.39; 1.16–1.67 <0.001 0.450 0% 300 mg, tid 2 [16 ] 285 1.29; 0.94–1.76 0.110 0.830 0%
a Mantel-Haenszel random-effects model. CI, confidential interval; FD, functional dyspepsia; NA, not applicable; RR, risk ratio; and tid, three times daily.