Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer

Table 1

Genes with disrupted or reduced efficiency binding sites, suggesting underexpression.

Gene symbol	rsID	miRNA	Allele change
RFFL	1859248	6 microRNAs	A G
		6 microRNAs	C G
		2 microRNAs	C T
		2 microRNAs	G T
	3744358	2 microRNAs	G T
		2 microRNAs	A G
		2 microRNAs	C G
		2 microRNAs	A C
		hsa-miR-3143	A T
		2 microRNAs	C T
	12947086	4 microRNAs	A G
APC	6594650	2 microRNAs	A C
	3733961	hsa-miR-5686	A G
FZD1	1052015	5 microRNAs	A C
	3750145	3 microRNAs	A G
	13403275	hsa-miR-4497	A G
FZD10	1046890	2 microRNAs	C T
	1046893	hsa-miR-4719	C G
	1046895	2 microRNAs	A G
	3741568	hsa-miR-4698	A G
	4760085	hsa-miR-5683	C G
PRICKLE2	14056	2 microRNAs	A G
	26937	3 microRNAs	A C
	26938	hsa-miR-552	G T
	26939	hsa-miR-92b-5p	A G
	27383	2 microRNAs	A G
	153732	hsa-miR-4490	A G
	17069879	hsa-miR-320e	A G
		8 micrRNAs	C G
SFRP1	1127379	3 microRNAs	A G
	3242	hsa-miR-4789-3p	C T
PDGFRA	7680422	hsa-miR-1256	A C
	1565664	3 micriRNAs	G T
KRAS	712	8 microRNAs	G T
	9266	5 microRNAs	C T
	12587	hsa-miR-506-5p	A C
	13096	2 microRNAs	A G
	1137282	hsa-miR-2681-5p	A T
		hsa-miR-2681-5p	C T
	7960917	hsa-miR-5700	C T
	7973623	hsa-miR-4495	A G
RAF1	12808	3 microRNAs	C T
	5746246	hsa-miR-548an	C T
	5746247	2 microRNAs	C T
ACVR2A	2854464	hsa-miR-149-5p	A G
	6734630	2 microRNAs	A G
	11831802	hsa-miR-411-5p	C T
	12993800	hsa-miR-5583-3p	C T
	13430086	hsa-miR-876-5p	A T
	17692648	hsa-miR-508-3p	A C
SMAD2	1981	hsa-miR-100-3p	C T
	1792671	2 microRNAs	A G
	8085335	hsa-miR-3653	A G
	8086227	hsa-miR-645	A G
	8098413	2 microRNAs	C T
	16958495	hsa-miR-3975	A G
	16958497	4 microRNAs	A T
	16958498	4 microRNAs	C T
	16958499	4 microRNAs	A C
	16958501	4 microRNAs	G T
	16958509	2 microRNAs	C T
SMAD3	1052488	2 microRNAs	C T
	3743342	6 microRNAs	C T
	8031440	3 microRNAs	A G
	8031627	hsa-miR-596	A G
	11556090	4 microRNAs	A G
	12900401	2 microRNAs	C T
SMAD4	4940037	2 microRNAs	A G
	16952798	3 microRNAs	A C
BCL2	1016860	4 microRNAs	A G
	1564483	hsa-miR-4440	A G
	3744937	hsa-miR-3911	C T
	4987843	4 microRNAs	A G
	4987847	2 microRNAs	A G
	4987848	2 microRNAs	A G
	4987850	2 microRNAs	A G
	4987852	hsa-miR-1229	A G
	4987853	2 microRNAs	A G
	4987854	hsa-miR-497-3p	A G
	4987855	2 microRNAs	A G
	4987856	hsa-miR-3160-5p	A G
	4987859	hsa-miR-3944-5p	A G
	4987861	2 microRNAs	C T
	4987865	2 microRNAs	A G
	4987868	3 microRNAs	A C
	4987869	2 microRNAs	A C
AXIN1	394128	hsa-miR-3649	C T
	393521	hsa-miR-653	G T
MET	1621	hsa-miR-1284	A G
	41739	2 microRNAs	A G
AXIN2	7591	3 microRNAs	A T
TCF7L2	1056877	4 microRNAs	C T
CCND1	7177	hsa-miR-939	A C
	7178	hsa-miR-4757-5p	A G
	3212895	2 microRNAs	A G
	3212896	3 microRNAs	G T
	3212905	hsa-miR-155-3p	A G
	3212908	3 microRNAs	C T
MLH3	108621	2 microRNAs	C T
	108622	3 microRNAs	A G
	175049	hsa-miR-573	C T
TP53	4968187	hsa-miR-3168	C T
	17882252	hsa-miR-3615	A G
	17879353	hsa-miR-4524b-3p	A C
PTEN	701848	hsa-miR-3658	C T
EPCAM	11554292	hsa-miR-466	A T
POLE	14302	7 microRNAs	C T
	5745091	7 microRNAs	A G
CDH1	13689	hsa-miR-4435	A C
		hsa-miR-4435	A T
		hsa-miR-4435	C T
		hsa-miR-4435	G T
	9282654	2 microRNAs	G T
CDKN2A	3088440	3 microRNAs	A G
		4 microRNAs	C G
		hsa-miR-1908	A C
		3 microRNAs	A T
		4 microRNAs	C T
		4 microRNAs	G T
	3731255	2 microRNAs	C G
	6413463	hsa-miR-3683	A T
TGFBR1	1590	2 microRNAs	A C
	334349	2 microRNAs	A G
	420549	hsa-miR-4753-3p	C G
	3739798	4 microRNAs	C T
	7850895	4 microRNAs	C T
	10988732	hsa-miR-384	C T
TGFBR2	11466531	hsa-miR-5708	C G
	11466533	hsa-miR-4329	A G
	11466534	4 microRNAs	A G
	11466536	11 microRNAs	C T
	11466537	hsa-miR-1193	A T
	17026332	2 microRNAs	A C
NRAS	14804	2 microRNAs	C T
	1815675	hsa-miR-3143	G T
	1988092	2 microRNAs	A T
	2793257	3 microRNAs	C G
	9724642	hsa-miR-1282	A G
	10516369	2 microRNAs	A T
IGF2	7873	hsa-miR-3191-3p	A G
DCC	2270954	2 microRNAs	A C
	12607853	2 microRNAs	C T
	16956878	2 microRNAs	C T
SOX9	1042667	hsa-miR-1181	A C
FAM123B	3810701	2 microRNAs	A C
	5964736	hsa-miR-450a-3p	C T
	28653713	2 microRNAs	G T