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The Scientific World Journal
Volume 2014 (2014), Article ID 563576, 9 pages
Clinical Study

Effects of Dietary Milled Seed Mixture on Fatty Acid Status and Inflammatory Markers in Patients on Hemodialysis

1Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, P.O. Box 102, 11000 Belgrade, Serbia
2Department of Nephrology and Dialysis, Clinical Hospital Zemun, University of Belgrade, Belgrade, Serbia
3Department of Endocrinology, Diabetes and Metabolism, Clinical Hospital Zemun, University of Belgrade, Belgrade, Serbia

Received 24 August 2013; Accepted 27 October 2013; Published 22 January 2014

Academic Editors: E. Kirk and E. van den Heuvel

Copyright © 2014 Danijela Ristic-Medic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Plant seeds have gained interest for their health benefits due to their fatty acid content. The objective of this study was to determine the effects of dietary consumption of milled sesame/pumpkin/flax seed mixture on glycemic control, serum lipids, phospholipid fatty acid status, and inflammatory factors in patients on hemodialysis. Methods. Thirty patients with well nutrition status (18 male, 12 female) were enrolled in the study. Participants consumed 30 g of milled sesame/pumpkin/flax (6 g/6 g/18 g, resp.) seeds mixture added to their habitual diet. Results. Total n-6 and n-3 polyunsaturated fatty acids and levels of linoleic, dihomo-gamma-linolenic (DGLA), arachidonic, alpha-linolenic (ALA), eicosapentaenoic, docosapentaenoic, and docosahexaenoic (DHA) acid were increased after 12 weeks of supplementation. A significant decrease of the serum triglyceride level ( ), glucose, insulin, calculated IR HOMA ( ), and inflammatory markers (TNF-alpha, IL-6, and hs-CRP, ) was observed after seed mixture treatment. The serum levels of CRP and TNF-alpha negative correlate with ALA, DHA, and DGLA. Conclusion. Results of this study indicated that dietary milled sesame/pumpkin/flax seed mixture added to a habitual diet lowered triglyceride and CRP, TNF-alpha, IL-6 levels, affect glycemic control and improved fatty acid profile and pruritus symptoms in hemodialysis patients.