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The Scientific World Journal
Volume 2014, Article ID 564573, 21 pages
Research Article

Significance of Algal Polymer in Designing Amphotericin B Nanoparticles

1PDMCOP, Bahadurgarh, Haryana 124507, India
2Department of Pharmaceutical Sciences, Jamia Hamdard, New Delhi 110062, India
3School of Pharmacy, Faculty of Applied Medical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India
4Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India

Received 7 July 2014; Revised 1 September 2014; Accepted 15 September 2014; Published 12 November 2014

Academic Editor: Rizwan Hasan Khan

Copyright © 2014 Saurabh Bhatia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Porphyra vietnamensis contains therapeutic polysaccharide called as Porphyran. There are various factors that influence the molecular weight of this red alga polysaccharide. Alkaline hydrolysis yields Porphyran with much better physical and chemical properties. Negative charge of this polysaccharide can be utilized for the preparation of polyelectrolyte complex. Therefore in this process PEC was prepared by using POR as negative and chitosan as positive polymer. Stable AmB nanoparticles were developed by polyelectrolyte complexation technique in the presence of TPP. These nanoparticles causes lysis of fungi as illustrated in supplementary data.

  1. Supplementary Material