Significance of Algal Polymer in Designing Amphotericin B Nanoparticles
Table 2
In vitro antifungal activity of AmB nanoformulations against commercial products and plain AmB ( minimum). IC50s of nanoformulations are expressed as equivalent concentration of AmB.
AmB nanoformulation and model drug
In vitro activity, IC50 SD (μg/mL) on
A. fumigatus
A. niger
A. flavus
C. albicans
24 h
48 h
24 h
48 h
24 h
48 h
24 h
48 h
AmB
1.44 ± 0.11
1.38 ± 0.01
1.68 ± 0.01
1.63 ± 0.07
1.33 ± 0.11
1.27 ± 0.33
0.59 ± 0.03
0.55 ± 0.08
Fungizone
0.49 ± 0.31
0.41 ± 0.02
0.57 ± 0.03
0.53 ± 0.01
0.41 ± 0.02∗∗∗
0.39 ± 0.14
0.29 ± 0.021
0.26 ± 0.013
AmBisome
1.92 ± 1.03
1.84 ± 0.02∗∗∗
2.01 ± 1.23
1.93 ± 0.02
1.69 ± 0.33∗∗∗
1.56 ± 0.02∗∗∗
0.52 ± 0.41
0.50 ± 1.14
CS-AMB-NP
0.50 ± 0.01
0.45 ± 0.03
0.74 ± 011
0.68 ± 0.03
1.56 ± 0.02
1.51 ± 1.11
0.26 ± 1.23
0.21 ± 0.01
CS-AMB-POR
0.10 ± 0.01
<0.08∗∗∗
0.17 ± 0.01
0.16 ± 0.02
0.12 ± 0.02
0.10 ± 0.03∗
0.08 ± 0.03∗∗∗
<0.04∗∗
CS-AMB-POR-TPP
0.16 ± 0.02
0.15 ± 1.11
0.11 ± 0.01
0.10 ± 1.37
0.11 ± 0.02
0.09 ± 0.01
0.08 ± 0.02∗∗∗
<0.03∗∗∗
in each group. Values are expressed as mean ± S.E.M. Data was analyzed by one-way ANOVA followed by Tukey’s post hoc test. ∗Significant difference with AmB, pb0.05. ∗∗Significant difference with AmB, pb0.01. ∗∗∗Significant difference with AmB, .
