Significance of Algal Polymer in Designing Amphotericin B Nanoparticles
Table 3
Dose (1, 4, and 8 mg/kg/day of AmB) related in vivo hematological responses of prepared formulations against marketed and reference drug.
Parameters
Doses (mg/kg/day)
Std. drug sol.
Fungizone
Ambisome
CS-AMB
CS-POR-AMB
CS-POR-AMB-TPP
Control
Blank
RBCs (×106/μL)
1
5.21 ± 0.3∗
5.77 ± 0.2
6.16 ± 1.3
6.18 ± 1.8
7.12 ± 1.5
7.08 ± 0.27
7.96 ± 1.8
8.12 ± 1.2
4
4.11 ± 1.2
4.81 ± 1.3
5.21 ± 1.1
5.53 ± 1.7
6.78 ± 1.8
6.31 ± 1.6
8
3.71 ± 1.1∗
4.07 ± 1.3∗
4.14 ± 0.3
4.11 ± 0.41
5.72 ± 1.2
5.22 ± 1.0
WBCs (×103/μL)
1
4.7 ± 0.3∗
5.1 ± 1.6
6.0 ± 1.1
5.9 ± 1.4
6.2 ± 0.7
5.8 ± 1.6
6.2 ± 1.1
5.9 ± 0.2
4
4.4 ± 1.3
4.6 ± 1.3
5.5 ± 1.4
5.7 ± 0.6
5.7 ± 1.2
5.3 ± 0.1
8
3.8 ± 0.8∗
4.8 ± 1.7∗
5.1 ± 1.8
4.9 ± 0.3
5.4 ± 1.1
5.2 ± 0.2
PL (×103/μL)
1
134 ± 23
178 ± 11
275 ± 18
281 ± 26
389 ± 41∗
371 ± 33
372 ± 21
433 ± 33∗
4
106 ± 28
144 ± 27
239 ± 23
237 ± 1.3
274 ± 11∗
266 ± 23
8
92 ± 11∗
116 ± 13∗
191 ± 16
182 ± 12
211 ± 31∗
207 ± 17
HT (%)
1
30.2 ± 2.4
32.1 ± 2.2
35.2 ± 3.1
34.1 ± 2.8
38.7 ± 3.4
38.2 ± 2.4
42.1 ± 3.1
41.1 ± 2.7
4
28.1 ± 3.1
30.7 ± 1.1
33.5 ± 2.1
31.1 ± 1.9
36.6 ± 3.1
35.2 ± 3.3
9
26.1 ± 2.5∗
29.1 ± 2.6∗
30.2 ± 1.7
29.1 ± 2.3
35.1 ± 1.7
34.1 ± 1.8
Hb (g/dL)
1
12.1 ± 1.3
13.2 ± 0.3
13.8 ± 0.2
13.3 ± 0.5
14.6 ± 3.2∗
14.3 ± 1.2
15.2 ± 1.4
15.1 ± 1.2
6
11.2 ± 1.1
12.4 ± 1.4
12.6 ± 1.6
12.1 ± 1.8
13.7 ± 0.3
13.6 ± 1.6
9
10.3 ± 0.2∗
11.1 ± 0.2
11.8 ± 0.1
11.7 ± 1.2
12.8 ± 1.3
12.7 ± 0.1
RBCs (red blood cells); WBCs (white blood cells); Hb (hemoglobin); PL (platelet); HT (hematocrit). ∗Significant ( < 0.05, all groups compared with control). in each group. Values are expressed as mean ± S.E.M. Data was analyzed by one-way ANOVA followed by Tukey’s post hoc test.
