The Scientific World Journal / 2014 / Article / Fig 5

Research Article

Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog, Pelophylax plancyi fukienensis: A Prototype of a Novel Class of Bradykinin Receptor Antagonist Peptide from Ranid Frogs

Figure 5

(a) Bradykinin dose-response curves using rat arterial smooth muscle in the absence (■) and presence (●) of ranakinestatin-PPF (generic name QUB2056) at a single dose of 10−6 M. (b) Relaxation effect of bradykinin on rat arterial smooth muscle at a single dose of 10−6 M and the effect of pretreatment with ranakinestatin-PPF (QUB 2056) at 10−6 M ( ), the bradykinin B2-receptor antagonist, HOE140 (3 × 10−7 M) ( ), and the bradykinin-B1-antagonist, desArg-HOE-140 (3 × 10−7 M) (NS—not significant). All data points represent the mean ± SEM of seven applications.