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The Scientific World Journal
Volume 2014, Article ID 575978, 5 pages
http://dx.doi.org/10.1155/2014/575978
Clinical Study

Sperm Cryopreservation before Testicular Cancer Treatment and Its Subsequent Utilization for the Treatment of Infertility

1Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Obilní trh 11, 602 00 Brno, Czech Republic
2Transfusion and Tissue Department, Faculty Hospital Brno, Jihlavská 20, 625 00 Brno, Czech Republic
3Department of Urology, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Jihlavská 20, 625 00 Brno, Czech Republic

Received 20 August 2013; Accepted 7 November 2013; Published 22 January 2014

Academic Editors: E. Baldi and A. Komiya

Copyright © 2014 Jana Žáková et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. In this study we report our results with storage of cryopreserved semen intended for preservation and subsequent infertility treatment in men with testicular cancer during the last 18 years. Methods. Cryopreserved semen of 523 men with testicular cancer was collected between October 1995 and the end of December 2012. Semen of 34 men (6.5%) was used for fertilization of their partners. They underwent 57 treatment cycles with cryopreserved, fresh, and/or donor sperm. Results. A total of 557 men have decided to freeze their semen before cancer treatment. Azoospermia was diagnosed in 34 men (6.1%), and semen was cryopreserved in 532 patients. Seminoma was diagnosed in 283 men (54.1%) and nonseminomatous germ cell tumors in 240 men (45.9%). 34 patients who returned for infertility treatment underwent 46 treatment cycles with cryopreserved sperm. Totally 16 pregnancies were achieved, that is, 34.8% pregnancy rate. Conclusion. The testicular cancer survivors have a good chance of fathering a child by using sperm cryopreserved prior to the oncology treatment, even when it contains only limited number of spermatozoa.