Classifying Lupus Nephritis: An Ongoing Story

Table 2

Active and chronic glomerular lesions specified by the 2004 ISN/RPS lupus nephritis classification.

Active lesions:
Endocapillary hypercellularity with or without
leukocyte
infiltration and with substantial luminal reduction
Karyorrhexis
Fibrinoid necrosis
Rupture of glomerular basement membrane
Crescents, cellular, or fibrocellular
Subendothelial deposits identified by light microscopy
(wire loops)
Intraluminal immune aggregates (hyaline thrombi)
Chronic lesions:
Glomerular sclerosis (segmental/global)
Fibrous adhesions
Fibrous crescents