Classifying Lupus Nephritis: An Ongoing Story

Table 4

Benefits and concerns of the ISN/RPS classification of LN.

Benefits:
(1) better clinical correlation
(2) effective communication between pathologists and clinicians
(3) improvement in reproducibility
(4) uniformity in reporting
(5) reliable outline for prospective studies
Concerns:
(1) loss of pathogenetic diversity of the classes
(2) failure to emphasize prognostic significance of
tubulointerstitial lesions
(3) unclarified role for subendothelial deposits in determining
the classes