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The Scientific World Journal
Volume 2014 (2014), Article ID 581657, 6 pages
http://dx.doi.org/10.1155/2014/581657
Clinical Study

Autoimmune Complications after Hematopoietic Stem Cell Transplantation in Children with Nonmalignant Disorders

1Department of Pediatric Hematology Oncology, Meyer Children’s Hospital, Rambam Health Care Campus, P.O. Box 9602, 31096 Haifa, Israel
2Department of Dermatology, Rambam Health Care Campus, Haifa, Israel
3Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
4Pediatric Hematology Oncology Department, Dana Children’s Hospital, Tel Aviv, Israel

Received 26 August 2013; Accepted 3 November 2013; Published 19 January 2014

Academic Editors: C. Hosing, M. Ota, and A. Saeid

Copyright © 2014 Abdalla Khalil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Tyndall and A. Gratwohl, “Haemopoietic stem and progenitor cells in the treatment of severe autoimmune diseases,” Annals of the Rheumatic Diseases, vol. 55, no. 3, pp. 149–151, 1996. View at Google Scholar · View at Scopus
  2. C. Peters and C. G. Steward, “Hematopoietic cell transplantation for inherited metabolic diseases: an overview of outcomes and practice guidelines,” Bone Marrow Transplantation, vol. 31, no. 4, pp. 229–239, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Di Bartolomeo, S. Santarone, E. Di Bartolomeo et al., “Long-term results of survival in patients with thalassemia major treated with bone marrow transplantation,” American Journal of Hematology, vol. 83, no. 7, pp. 528–530, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Porta, C. Forino, D. De Martiis et al., “Stem cell transplantation for primary immunodeficiencies,” Bone Marrow Transplantation, vol. 41, supplement 2, pp. S83–S86, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Sviland, “The pathology of bone marrow transplantation,” Current Diagnostic Pathology, vol. 6, no. 4, pp. 242–250, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Khalil, A. B. Barak, I. Zaidman, R. Elhasid, J. M. Rowe, and M. Ben-Arush, “Polyserositis as a manifestation of graft-versus-host disease,” Pediatric Hematology and Oncology, vol. 28, no. 8, pp. 691–693, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Bashey, I. Owen, G. F. Lucas et al., “Late onset immune pancytopenia following bone marrow transplantation,” British Journal of Haematology, vol. 78, no. 2, pp. 268–274, 1991. View at Google Scholar · View at Scopus
  8. A. Hartert, W. Willenbacher, S. Günzelmann et al., “Successful treatment of thrombocytopenia and hemolytic anemia with IvIG in a patient with lupus-like syndrome after mismatched related PBSCT,” Bone Marrow Transplantation, vol. 27, no. 3, pp. 337–340, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. T. R. Klumpp, “Immunohematologic complications of bone marrow transplantation,” Bone Marrow Transplantation, vol. 8, no. 3, pp. 159–170, 1991. View at Google Scholar · View at Scopus
  10. R. M. Minchinton, A. H. Waters, J. Kendra, and A. J. Barrett, “Autoimmune thrombocytopenia acquired from an allogeneic bone-marrow graft,” The Lancet, vol. 2, no. 8299, pp. 627–629, 1982. View at Google Scholar · View at Scopus
  11. C. A. Mullen, J. N. Thompson, L. A. Richard, and K. W. Chan, “Unrelated umbilical cord blood transplantation in infancy for mucopolysaccharidosis type IIB (Hunter syndrome) complicated by autoimmune hemolytic anemia,” Bone Marrow Transplantation, vol. 25, no. 10, pp. 1093–1099, 2000. View at Google Scholar · View at Scopus
  12. F. E. Chen, I. Owen, D. Savage et al., “Late onset haemolysis and red cell autoimmunisation after allogeneic bone marrow transplant,” Bone Marrow Transplantation, vol. 19, no. 5, pp. 491–495, 1997. View at Google Scholar · View at Scopus
  13. T. A. O'Brien, T. Eastlund, C. Peters et al., “Autoimmune haemolytic anaemia complicating haematopoietic cell transplantation in paediatric patients: high incidence and significant mortality in unrelated donor transplants for non-malignant diseases,” British Journal of Haematology, vol. 127, no. 1, pp. 67–75, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Horn, M. Viele, W. Mentzer, N. Mogck, K. DeSantes, and M. Cowan, “Autoimmune hemolytic anemia in patients with SCID after T cell-depleted BM and PBSC transplantation,” Bone Marrow Transplantation, vol. 24, no. 9, pp. 1009–1013, 1999. View at Google Scholar · View at Scopus
  15. W. Y. Au, A. K. W. Lie, A. W. C. Kung, R. Liang, B. R. Hawkins, and Y. L. Kwong, “Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation,” Bone Marrow Transplantation, vol. 35, no. 4, pp. 383–388, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. A. M. Marmont, “Autoimmunity and allogeneic bone marrow transplantation,” Bone Marrow Transplantation, vol. 9, no. 1, pp. 1–3, 1992. View at Google Scholar · View at Scopus
  17. C. M. Dayan and G. H. Daniels, “Chronic autoimmune thyroiditis,” New England Journal of Medicine, vol. 335, no. 2, pp. 99–107, 1996. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Karthaus, T. Gabrysiak, G. Brabant et al., “Immune thyroiditis after transplantation of allogeneic CD34+ selected peripheral blood cells,” Bone Marrow Transplantation, vol. 20, no. 8, pp. 697–699, 1997. View at Google Scholar · View at Scopus
  19. E. L. Krawitt, “Autoimmune hepatitis,” New England Journal of Medicine, vol. 354, no. 1, pp. 54–66, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Ogose, T. Watanabe, H. Suzuya et al., “Autoimmune hepatitis following allogeneic PBSCT from an HLA-matched sibling,” Bone Marrow Transplantation, vol. 31, no. 9, pp. 829–832, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Andries, L. Casamayou, C. Sempoux et al., “Posttransplant immune hepatitis in pediatric liver transplant recipients: incidence and maintenance therapy with azathioprine,” Transplantation, vol. 72, no. 2, pp. 267–272, 2001. View at Google Scholar · View at Scopus
  22. M. P. Manns and A. Vogel, “Autoimmune hepatitis, from mechanisms to therapy,” Hepatology, vol. 43, supplement 2, pp. S132–S144, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Sherer and Y. Shoenfeld, “Autoimmune diseases and autoimmunity post-bone marrow transplantation,” Bone Marrow Transplantation, vol. 22, no. 9, pp. 873–881, 1998. View at Google Scholar · View at Scopus
  24. J. G. Damoiseaux and P. J. Van Breda Vriesman, “Pathogenesis of cyclosporin A-induced autoimmunity: absence of T-cell reactivity to wards syngeneic antigen presenting cells,” Autoimmunity, vol. 27, no. 1, pp. 45–56, 1998. View at Google Scholar · View at Scopus
  25. S. Habib, M. A. Nalesnik, J. Ahmad, D. BuchBarker, and A. O. Shakil, “Alloimmune hepatitis following peripheral stem cell transplantation,” Bone Marrow Transplantation, vol. 39, no. 9, pp. 573–575, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Maggiore, F. Veber, O. Bernard et al., “Autoimmune hepatitis associated with anti-actin antibodies in children and adolescents,” Journal of Pediatric Gastroenterology and Nutrition, vol. 17, no. 4, pp. 376–381, 1993. View at Google Scholar · View at Scopus
  27. S. B. Cho, M. R. Roh, K. Y. Chung, K. Lee, and Y. Park, “Generalized vitiligo after allogeneic bone marrow transplantation,” Acta Dermato-Venereologica, vol. 85, no. 1, pp. 82–83, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. G. S. Ogg, P. R. Dunbar, P. Romero, J. Chen, and V. Cerundolo, “High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo,” Journal of Experimental Medicine, vol. 188, no. 6, pp. 1203–1208, 1998. View at Publisher · View at Google Scholar · View at Scopus
  29. E. H. Kemp, N. G. Gavalas, D. J. Gawkrodger, and A. P. Weetman, “Autoantibody responses to melanocytes in the depigmenting skin disease vitiligo,” Autoimmunity Reviews, vol. 6, no. 3, pp. 138–142, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Fimiani, G. De Aloe, and A. Cuccia, “Chronic graft versus host disease and skin,” Journal of the European Academy of Dermatology and Venereology, vol. 17, no. 5, pp. 512–517, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. P. F. Penas, M. Jones-Caballero, M. Aragues, J. Frenandez-Herrera, J. Fraga, and A. Garcia-Diez, “Sclerodermatous graft-versus-host disease,” Archives of Dermatology, vol. 138, no. 7, pp. 924–934, 2002. View at Google Scholar
  32. H. Sanli, B. N. Akay, M. Arat et al., “Vitiligo after hematopoietic cell transplantation: six cases and review of the literature,” Dermatology, vol. 216, no. 4, pp. 349–354, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. J. M. White, D. Creamer, A. W. P. du Vivier et al., “Sclerodermatous graft-versus-host disease: clinical spectrum and therapeutic challenges,” British Journal of Dermatology, vol. 156, no. 5, pp. 1032–1038, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. N. F. Olivieri, D. G. Nathan, J. H. MacMillan et al., “Survival in medically treated patients with homozygous beta-thalassemia,” The New England Journal of Medicine, vol. 331, no. 9, pp. 574–578, 1994. View at Publisher · View at Google Scholar