Stability of Ceftiofur Sodium and Cefquinome Sulphate in Intravenous Solutions

Table 1

Stability of ceftiofur sodium stored in poly(vinyl chloride) minibags.

22°C			6°C
Intravenous solution	t (day)	c (%)	Intravenous solution	t (day)	c (%)
Water for injection	0	100.00	Water for injection	0	100.00
	2	98.85		3	99.02
	6	97.62		12	97.13
	23	91.92		28	94.23
Glucose 0.1 mg/mL	0	100.00	Glucose 0.1 mg/mL	0	100.00
	2	98.40		3	99.28
	6	95.61		12	97.21
	23	82.87		28	91.35
Glucose 0.2 mg/mL	0	100.00	Glucose 0.2 mg/mL	0	100.00
	2	97.73		3	98.39
	6	92.27		12	94.96
	23	72.86		28	89.59
Mixture of 9 μg/mL sodium chloride and 0.05 mg/mL glucose (1 : 2 𝑉/𝑉)	0	100.00	Mixture of 9 μg/mL sodium chloride and 0.05 mg/mL glucose (1 : 2 𝑉/𝑉)	0	100.00
	2	98.14		3	99.32
	6	96.10		12	98.80
	23	87.33		28	97.05
Solutio Ringeri	0	100.00	Solutio Ringeri	0	100.00
	2	98.71		3	99.14
	6	97.78		12	97.76
	23	92.60		28	95.77
Solutio Ringeri Lactate	0	100.00	Solutio Ringeri Lactate	0	100.00
	2	99.18		3	99.46
	6	96.30		12	98.81
	23	87.65		28	97.56
Multielectrolytic isotonic fluid	0	100.00	Multielectrolytic isotonic fluid	0	100.00
	2	100.16		3	99.12
	6	Precipitation		12	98.04
				28	95.11
Pediatric fluid	0	100.00	Pediatric fluid	0	100.00
	2	99.56		3	99.65
	6	Precipitation		12	99.21
				28	98.12
Sodium chloride 9 μg/mL	0	100.00	Sodium chloride 9 μg/mL	0	100.00
	2	100.02		3	99.61
	6	Precipitation		12	99.02
				28	97.88
Glucose 0.05 mg/mL	0	100.00	Glucose 0.05 mg/mL	0	100.00
	2	100.15		3	99.02
	6	Precipitation		12	97.88
				28	94.79
Mixture of 9 μg/mL sodium chloride and 0.05 mg/mL glucose (1 : 1 𝑉/𝑉)	0	100.00	Mixture of 9 μg/mL sodium chloride and 0.05 mg/mL glucose (1 : 1 𝑉/𝑉)	0	100.00
	2	99.77		3	99.44
	6	Precipitation		12	98.72
				28	96.15

c (%): percent of initial concentration.