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The Scientific World Journal
Volume 2014, Article ID 595962, 6 pages
Review Article

Effect of Probiotics Supplementation on Bone Mineral Content and Bone Mass Density

1Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
2Department of Orthopaedics and Traumatology, Faculty of Medicine, Universiti Kebengsaan Malaysia, 56000 Kuala Lumpur, Malaysia

Received 31 August 2013; Accepted 20 November 2013; Published 22 January 2014

Academic Editors: A. Chicco, S. E. Harris, J. Khan, and B. Venn

Copyright © 2014 Kolsoom Parvaneh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A few studies in animals and a study in humans showed a positive effect of probiotic on bone metabolism and bone mass density. Most of the investigated bacteria were Lactobacillus and Bifidobacterium . The positive results of the probiotics were supported by the high content of dietary calcium and the high amounts of supplemented probiotics. Some of the principal mechanisms include (1) increasing mineral solubility due to production of short chain fatty acids; (2) producing phytase enzyme by bacteria to overcome the effect of mineral depressed by phytate; (3) reducing intestinal inflammation followed by increasing bone mass density; (4) hydrolysing glycoside bond food in the intestines by Lactobacillus and Bifidobacteria. These mechanisms lead to increase bioavailability of the minerals. In conclusion, probiotics showed potential effects on bone metabolism through different mechanisms with outstanding results in the animal model. The results also showed that postmenopausal women who suffered from low bone mass density are potential targets to consume probiotics for increasing mineral bioavailability including calcium and consequently increasing bone mass density.