Figure 3: Effects of pioglitazone on ACE2 protein expression in insulin-sensitive tissues in rats fed a high-fat diet. In liver, adipose tissue, and skeletal muscle, ACE2 protein expression was significantly greater in the HP group compared with the HFD group. NC, normal control; HFD, high-fat diet; PC, pioglitazone control; HP, high-fat diet plus pioglitazone.