Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014, Article ID 614265, 11 pages
http://dx.doi.org/10.1155/2014/614265
Research Article

In Vivo Hypoglycaemic Effect and Inhibitory Mechanism of the Branch Bark Extract of the Mulberry on STZ-Induced Diabetic Mice

Silk Biotechnology Laboratory, School of Biology and Basic Medical Sciences, Soochow University, RM 702-2303, No. 199, Renai Road, Dushuhu Higher Edu. Town, Suzhou 215123, China

Received 5 June 2014; Revised 15 July 2014; Accepted 15 July 2014; Published 6 August 2014

Academic Editor: Juei-Tang Cheng

Copyright © 2014 Hua-Yu Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Shu, P. Lu, and N. He, “Mercury adsorption of modified mulberry twig chars in a simulated flue gas,” Bioresource Technology, vol. 136, pp. 182–187, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. X. X. Lu and G. L. Liao, “Method for planting lentinus edodes by using mulberry branch wood chips as planting material,” Patent CN CN101627697 B, 8, 2010. View at Google Scholar
  3. S. B. Zhang, “White-mulberry-branch composite decorative plate,” Pat. CN, CN2816184Y, 2006.
  4. K. Doi, T. Kojima, and Y. Fujimoto, “Mulberry leaf extract inhibits the oxidative modification of rabbit and human low density lipoprotein,” Biological and Pharmaceutical Bulletin, vol. 23, no. 9, pp. 1066–1071, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Kobayashi, M. Miyazawa, A. Kamei, K. Abe, and T. Kojima, “Ameliorative effects of mulberry (Morus alba L.) leaves on hyperlipidemia in rats fed a high-fat diet: induction of fatty acid oxidation, inhibition of lipogenesis, and suppression of oxidative stress,” Bioscience, Biotechnology and Biochemistry, vol. 74, no. 12, pp. 2385–2395, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. X. M. Liu, L. Li, Y. J. Wang, M. Fang, and Y. Q. Zhang, “Effects of mulberry branch bark extract on serum lipid levels of acute hyperlipidemic mice,” Science of Sericulture, vol. 37, no. 4, pp. 771–774, 2011 (Chinese). View at Google Scholar
  7. W. Fu, Y. F. Lei, Y. L. Cai, D. N. Zhou, and J. L. Ruan, “A new alkylene dihydrofuran glycoside with antioxidation activity from the root bark of Morus alba L.,” Chinese Chemical Letters, vol. 21, no. 7, pp. 821–823, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Kikuchi, M. Nihei, H. Nagai et al., “Albanol a from the root bark of Morus alba L. induces apoptotic cell death in HL60 human leukemia cell line,” Chemical and Pharmaceutical Bulletin, vol. 58, no. 4, pp. 568–571, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. K. M. Park, J. S. You, H. Y. Lee, N. I. Baek, and J. K. Hwang, “Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens,” Journal of Ethnopharmacology, vol. 84, no. 2-3, pp. 181–185, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Balasubramanian, K. Ramalingam, S. Krishnan, and C. Ajm, “Anti-inflammatory activity of Morus indica Linn,” Iranian Journal of Pharmacology & Therapeutics, vol. 4, no. 1, pp. 13–15, 2005. View at Google Scholar
  11. M. M. Padilha, F. C. Vilela, C. Q. Rocha et al., “Antiinflammatory properties of Morus nigra leaves,” Phytotherapy Research, vol. 24, no. 10, pp. 1496–1500, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Dai, Z. Mi, Z. Ma, S. Li, R. Chen, and D. Yu, “Bioactive diels-alder type adducts from the stem bark of Morus macroura,” Planta Medica, vol. 70, no. 8, pp. 758–763, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Dai, Y. Wu, Y. Wang, W. He, R. Chen, and D. Yu, “New diels-alder type adducts from Morus macroura and their anti-oxidant activities,” Chemical and Pharmaceutical Bulletin, vol. 52, no. 10, pp. 1190–1193, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. X. R. Zhu, J. M. Fei, Y. W. Yang, and K. Yang, “Preliminary investigation on resveratrol content in mulberry pericarp and branch,” Science of Sericulture, vol. 33, no. 1, pp. 110–113, 2007. View at Google Scholar
  15. Z. F. Zhang, J. Jin, and L. G. Shi, “Antioxidant activity of the derivatives of polysaccharide extracted from a Chinese medical herb (Ramulus mori),” Food Science and Technology Research, vol. 14, no. 2, pp. 160–168, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. Z. Zhang and L. Shi, “Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori,” Fitoterapia, vol. 81, no. 3, pp. 214–218, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Tan, R. Yan, H. Wang, R. Chen, and D. Yu, “Wittiorumins A-F, antioxidant Diels-Alder-type adducts from Morus wittiorum,” Planta Medica, vol. 75, no. 3, pp. 249–255, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. G. Li, D. Ji, S. Zhong et al., “Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice,” Journal of Ethnopharmacology, vol. 134, no. 3, pp. 961–970, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. T. L. Kang, S. L. Kwang, H. J. Ji, K. J. Byoung, Y. H. Moon, and P. K. Hyun, “Inhibitory effects of Ramulus mori extracts on melanogenesis,” Journal of Cosmetic Science, vol. 54, no. 2, pp. 133–142, 2003. View at Google Scholar · View at Scopus
  20. J. H. Kim and K. T. Lee, “Whitening cosmetics containing solvent-fractionated extracts of mulberry branch bark extract,” Patent WO US6197304, 2001.
  21. Y.-W. Shi, C.-P. Wang, X. Wang et al., “Uricosuric and nephroprotective properties of Ramulus Mori ethanol extract in hyperuricemic mice,” Journal of Ethnopharmacology, vol. 143, no. 3, pp. 896–904, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Zhang, J. Jin, and L. Shi, “Protective function of cis-mulberroside A and oxyresveratrol from Ramulus mori against ethanol-induced hepatic damage,” Environmental Toxicology and Pharmacology, vol. 26, no. 3, pp. 325–330, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. K. Lee, D. Y. Yuk, T. I. Kim et al., “Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity,” Journal of Natural Medicines, vol. 63, no. 3, pp. 274–282, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Z. Li, Compendium of Materia Medica, People's Medical Publishing House, Beijing, China, 1976 (Chinese).
  25. S. Su and Z. J. Shang, “Bencao Tujing,” 342, Anhui Science and Technology Publishing House, Chinese, 1994.
  26. M. Z. Xie, Z. F. Shen, and L. L. Zhu, “Traditional Chinese medicinal composition with reducing-blood-sugar activity,” Pat. CN. CN1082374C, 1998. View at Google Scholar
  27. H. Nojima, I. Kimura, F.-J. Chen et al., “Antihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice,” Journal of Natural Products, vol. 61, no. 3, pp. 397–400, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. A. N. B. Singab, H. A. El-Beshbishy, M. Yonekawa, T. Nomura, and T. Fukai, “Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats,” Journal of Ethnopharmacology, vol. 100, no. 3, pp. 333–338, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Q. Ma, Z. J. Jing, S. Q. Xu, X. Yu, X. M. Hu, and H. Pan, “Effects of flavonoids in Morus indica on blood lipids and glucose in hyperlipidemia-diabetic rats,” Chinese Herbal Medicine, vol. 4, no. 4, pp. 314–318, 2012. View at Google Scholar
  30. K. Tanabe, S. Nakamura, K. Omagari, and T. Oku, “Repeated ingestion of the leaf extract from Morus alba reduces insulin resistance in KK-Ay mice,” Nutrition Research, vol. 31, no. 11, pp. 848–854, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Y. Zhang, W. Chen, T. C. Wang, and J. Z. Liu, “Determination of DNJ of mulberry latex and evaluation of the hypoglycemic effect on mice,” Advanced Materials Research, vol. 175-176, pp. 36–40, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. W. Q. Liu and X. R. Zhu, “The determination of 1-deoxynojirimycin (DNJ) in three parts of mulberry,” Bull Sericulture, vol. 37, no. 4, pp. 31–33, 2006. View at Google Scholar
  33. F. Ye, Z. F. Shen, F. X. Qiao, D. Y. Zhao, and M. Z. Xie, “Experimental treatment of complications in alloxan diabetic rats with α-glucosidase inhibitor from the Chinese Medicinal Herb mulberry branch bark,” Acta Pharmacologica Sinica, vol. 37, no. 2, pp. 108–112, 2002. View at Google Scholar
  34. F. Ye, Z. Shen, and M. Xie, “Alpha-glucosidase inhibition from a Chinese medical herb (Ramulus mori) in normal and diabetic rats and mice,” Phytomedicine, vol. 9, no. 2, pp. 161–166, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. L. Ma, Y. Q. Zhang, and L. X. Zhou, “The antioxidation and inhibitory effects of mulberry bark ethanol extract on α-glucosidase activity,” Science of Sericulture, vol. 36, no. 1, pp. 143–147, 2010 (Chinese). View at Google Scholar
  36. C. Guo, R. Li, N. Zheng, L. Xu, T. Liang, and Q. He, “Anti-diabetic effect of ramulus mori polysaccharides, isolated from Morus alba L., on STZ-diabetic mice through blocking inflammatory response and attenuating oxidative stress,” International Immunopharmacology, vol. 16, no. 1, pp. 93–99, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. Q. Zhang, Y. L. Ma, L. X. Zhou, H. B. Yan, and W. D. Shen, “Mulberry bark extract capable of reducing blood sugar and preparation method thereof,” Patent CN200810021592, 2008. View at Google Scholar
  38. K. Yatsunami, Y. Saito, E. Fukuda, S. Onodera, and K. Oshigane, “α-Glucosidase inhibitory activity in leaves of some mulberry varieties,” Food Science and Technology Research, vol. 9, no. 4, pp. 392–394, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. G. Li, D. F. Ji, S. Zhong et al., “1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice,” Scientific Reports, vol. 3, article 1377, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Wang, M. Fang, Y. L. Ma, and Y. Q. Zhang, “Preparation of the branch bark ethanol extract in mulberry Morus alba, its antioxidation and antihyperglycemic activity in vivo,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 569652, 7 pages, 2014. View at Publisher · View at Google Scholar
  41. K. R. Venkatesh and C. Seema, “Mulberry: life enhancer,” Journal of Medicinal Plants Research, vol. 2, no. 10, pp. 271–278, 2008. View at Google Scholar
  42. M. Fang, A. Q. Huang, and Y. Q. Zhang, “The correlation between 1-deoxynojirimycin content and α-glucosidase inhibitory activity in the bark ethanol extract from Ramulus mori,” in Proceedings of the International Conference on Biomedical Engineering and Biotechnology (iCBEB '12), pp. 1795–1798, May 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. L. N. Song and J. M. Song, “Research advancement about insulin resistance of β-cells,” Medical Recapitulate, vol. 15, pp. 440–442, 2009. View at Google Scholar