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The Scientific World Journal
Volume 2014, Article ID 616534, 9 pages
Review Article

Hypoglycemia Induced by Insulin as a Triggering Factor of Cognitive Deficit in Diabetic Children

Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil

Received 28 December 2013; Accepted 18 February 2014; Published 23 March 2014

Academic Editors: G. B. Melis and A. Schreiber

Copyright © 2014 Vanessa Rodrigues Vilela et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper provides an overview of insulin-induced hypoglycemia as a triggering factor of cognitive deficit in children with type 1 diabetes mellitus. For this purpose, databases from 1961 to 2013 were used with the objective of detecting the primary publications that address the impact of hypoglycemia on cognitive performance of diabetic children. The results obtained from experimental animals were excluded. The majority of studies demonstrated that the cognitive deficit in diabetic children involves multiple factors including duration, intensity, severity, and frequency of hypoglycemia episodes. Additionally, age at the onset of type 1 diabetes also influences the cognitive performance, considering that early inception of the disease is a predisposing factor for severe hypoglycemia. Furthermore, the results suggest that there is a strong correlation between brain damage caused by hypoglycemia and cognitive deterioration. Therefore, a more cautious follow-up and education are needed to impede and treat hypoglycemia in children with diabetes mellitus.