The Scientific World Journal / 2014 / Article / Tab 1

Review Article

VEGF Genetic Polymorphisms May Contribute to the Risk of Diabetic Nephropathy in Patients with Diabetes Mellitus: A Meta-Analysis

Table 1

Baseline characteristics and methodological quality of all included studies.

First authorYearCountryEthnicitySample sizeGender (M/F)Age (years)Genotyping methodSNP typeHWE test (P value)NOS score
DNDMDNDMDNDM

Bonnefond [18]2013FranceCaucasian151010581917/5936739/384264.3 ± 10.062.9 ± 10.1TaqManrs6921438 Y/X0.9537
60.4 ± 9.7rs10738760 Y/X0.095
Nikzamir [23]2012IranAsian255235129/126106/12959.6 ± 8.158.4 ± 7.6PCR-RFLPrs2010963 G/C0.4016
Xiao [25]2011ChinaAsian11110563/4855/5063.4 ± 6.860.5 ± 6.2PCR-ASArs699947 G/A0.1187
Zhang [26]2008ChinaAsian1029254/4844/4859.9 ± 12.461.6 ± 10.4PCR-RFLPrs3025039 C/T0.0637
Zhang [34]2008ChinaAsian17312363.7 ± 10.662.7 ± 9.9PCR-RFLPrs3025039 C/T0.5817
Guo [30]2008ChinaAsian817641/4035/4159.6 ± 10.957.1 ± 10.9PCR-RFLPrs2010963 G/C0.4257
rs833061 C/T0.172
Xue [33]2007ChinaAsian976044/5329/3165.6 ± 11.6PCR-RFLP−2549 D/I0.3688
McKnight [22]2007UKCaucasian242301149/93122/17917.6 ± 9.015.9 ± 8.4Pyrosequencingrs3025039 C/T0.7127
TaqManrs699947 G/A0.182
Pyrosequencingrs2010963 G/C0.055
Buraczynska [24]2007PolandCaucasian24591126/11943/4857.9 ± 10.756.9 ± 9.8PCR-RFLP−2549 D/I0.6798
rs2010963 G/C0.652
He [31]2007ChinaAsian12912064/6556/6462.9 ± 12.061.6 ± 15.3PCR-RFLPrs3025039 C/T0.6617
Li [32]2005ChinaAsian10411258/5450/4862.1 ± 7.060.0 ± 6.8PCR-RFLPrs2010963 G/C0.5118

DN: diabetic nephropathy; DM: diabetes mellitus; M: male; F: female; SNP: single nucleotide polymorphism; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; PCR-ASA: polymerase chain reaction-amplicon sequence analysis; HWE: Hardy-Weinberg equilibrium; NOS: the Newcastle-Ottawa Scale.