Review Article
[Retracted] VEGF Genetic Polymorphisms May Contribute to the Risk of Diabetic Nephropathy in Patients with Diabetes Mellitus: A Meta-Analysis
Table 1
Baseline characteristics and methodological quality of all included studies.
| | First author | Year | Country | Ethnicity | Sample size | Gender (M/F) | Age (years) | Genotyping method | SNP type | HWE test (P value) | NOS score | | DN | DM | DN | DM | DN | DM |
| | Bonnefond [18] | 2013 | France | Caucasian | 1510 | 10581 | 917/593 | 6739/3842 | 64.3 ± 10.0 | 62.9 ± 10.1 | TaqMan | rs6921438 Y/X | 0.953 | 7 | | | | | | | | | | | 60.4 ± 9.7 | | rs10738760 Y/X | 0.095 | | | Nikzamir [23] | 2012 | Iran | Asian | 255 | 235 | 129/126 | 106/129 | 59.6 ± 8.1 | 58.4 ± 7.6 | PCR-RFLP | rs2010963 G/C | 0.401 | 6 | | Xiao [25] | 2011 | China | Asian | 111 | 105 | 63/48 | 55/50 | 63.4 ± 6.8 | 60.5 ± 6.2 | PCR-ASA | rs699947 G/A | 0.118 | 7 | | Zhang [26] | 2008 | China | Asian | 102 | 92 | 54/48 | 44/48 | 59.9 ± 12.4 | 61.6 ± 10.4 | PCR-RFLP | rs3025039 C/T | 0.063 | 7 | | Zhang [34] | 2008 | China | Asian | 173 | 123 | — | — | 63.7 ± 10.6 | 62.7 ± 9.9 | PCR-RFLP | rs3025039 C/T | 0.581 | 7 | | Guo [30] | 2008 | China | Asian | 81 | 76 | 41/40 | 35/41 | 59.6 ± 10.9 | 57.1 ± 10.9 | PCR-RFLP | rs2010963 G/C | 0.425 | 7 | | | | | | | | | | | | | rs833061 C/T | 0.172 | | | Xue [33] | 2007 | China | Asian | 97 | 60 | 44/53 | 29/31 | — | 65.6 ± 11.6 | PCR-RFLP | −2549 D/I | 0.368 | 8 | | McKnight [22] | 2007 | UK | Caucasian | 242 | 301 | 149/93 | 122/179 | 17.6 ± 9.0 | 15.9 ± 8.4 | Pyrosequencing | rs3025039 C/T | 0.712 | 7 | | | | | | | | | | | | TaqMan | rs699947 G/A | 0.182 | | | | | | | | | | | | | Pyrosequencing | rs2010963 G/C | 0.055 | | | Buraczynska [24] | 2007 | Poland | Caucasian | 245 | 91 | 126/119 | 43/48 | 57.9 ± 10.7 | 56.9 ± 9.8 | PCR-RFLP | −2549 D/I | 0.679 | 8 | | | | | | | | | | | | | rs2010963 G/C | 0.652 | | | He [31] | 2007 | China | Asian | 129 | 120 | 64/65 | 56/64 | 62.9 ± 12.0 | 61.6 ± 15.3 | PCR-RFLP | rs3025039 C/T | 0.661 | 7 | | Li [32] | 2005 | China | Asian | 104 | 112 | 58/54 | 50/48 | 62.1 ± 7.0 | 60.0 ± 6.8 | PCR-RFLP | rs2010963 G/C | 0.511 | 8 |
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DN: diabetic nephropathy; DM: diabetes mellitus; M: male; F: female; SNP: single nucleotide polymorphism; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; PCR-ASA: polymerase chain reaction-amplicon sequence analysis; HWE: Hardy-Weinberg equilibrium; NOS: the Newcastle-Ottawa Scale.
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