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The Scientific World Journal
Volume 2014, Article ID 634935, 10 pages
Research Article

A Novel One-Pot and One-Step Microwave-Assisted Cyclization-Methylation Reaction of Amino Alcohols and Acetylated Derivatives with Dimethyl Carbonate and TBAC

1Centro de Graduados e Investigación en Química del Instituto Tecnológico de Tijuana, Boulevard Alberto Limón Padilla S/N 22510 Tijuana, BC, Mexico
2Área de Ciencias Básicas e Ingenierías, Universidad Autónoma de Nayarit, Cd. de la Cultura Amado Nervo S/N 63190 Tepic, Nay, Mexico

Received 12 April 2014; Revised 19 August 2014; Accepted 20 August 2014; Published 14 October 2014

Academic Editor: Antal Tungler

Copyright © 2014 Adrián Ochoa-Terán et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A simple and efficient microwave-assisted methodology for the synthesis of 4-substituted-3-methyl-1,3-oxazolidin-2-ones from amino alcohols catalyzed by a ionic liquid was developed. This novel one-pot and one-step cyclization-methylation reaction represents an easier and faster method than any other reported protocols that can be used to obtain the desired products in good yields and high purity. Applying microwave irradiation at 130°C in the presence of TBAC, dimethyl carbonate acts simultaneously as carbonylating and methylating agent and surprisingly promotes an in situ basic trans esterification when a N-acetylated amino alcohol is used as starting material. Furthermore, dimethyl carbonate worked better than diethyl carbonate in performing this reaction.