Clinical and Renal Biopsy Findings Predicting Outcome in Renal Thrombotic Microangiopathy: A Large Cohort Study from a Single Institute in China

Table 3

Prognosis of patients with thrombotic microangiopathy.

Etiologies or associated disorders; (109 patients in total)	CR (%)	PR (%)	TF (%)	Primary end point (%)	Secondary end point
					Doubling of Cr (%)	ESRD (%)
D + HUS ()	1 (100)	0	0	0	0	0
aHUS ()	2 (28.5)	0	5 (71.5)	1 (14.3)	0	4 (57.1)
MHT ()	12 (19.7)	0	49 (80.3)	5 (8.2)	16 (26.2)	28 (45.9)
Pregnancy
Preeclampsia/HELLP ()	4 (80.0)	0	1 (20.0)	0	0	1 (20.0)
HUS ()	6 (66.7)	0	3 (33.3)	0	0	3 (33.3)
Others
Connective tissue disorders ()	11 (64.7)	1 (5.9)	5 (29.4)	1 (5.9)	0	4 (23.5)
HSCT ()	1 (50.0)	1 (50.0)	0	0	0	0
Castleman’s disease ()	2 (50.0)	0	2 (50.0)	1 (25.0)	1 (25.0)	0
Cryoglobulinemia ()	1 (100)	0	0	0	0	0
Glomerulopathy ()	1 (50.0)	1 (50.0)	0	0	0	0

Notes: CR: complete remission; PR: partial remission; TF: treatment failure; Cr: creatinine; ESRD: end stage renal disease; D + HUS: diarrhea positive hemolytic uremic syndrome; aHUS: atypical hemolytic uremic syndrome; MHT: malignant hypertension; HELLP: hemolysis, elevated live enzymes, low platelet count; HSCT: hematopoietic stem cell transplantation.