Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes

Table 1

ICL inhibition activity of selected salicylanilide diethyl phosphates 1.

	R^1	R^2	% ICL inhibition at 10 M; (±standard deviation)
1a	4-Br	3-F	7 ± 2.45
1h	4-Br	4-Br	6 ± 2.41
1s	5-Cl	3-Cl	6 ± 0.83
1u	5-Cl	3-F	4 ± 0.50
1v	5-Cl	4-F	6 ± 0.92
1w	5-Cl	4-Br	6 ± 1.00
1x	5-Cl	4-Cl	6 ± 1.31
3-Nitropropionic acid			25 ± 4.1
Isoniazid			0

Esters, which are not reported here, had no ICL inhibition.