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The Scientific World Journal
Volume 2014, Article ID 705259, 11 pages
Research Article

Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting

1Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India
2NKBR College of Pharmacy & Research Centre, Meerut, Uttar Pradesh, India
3Government College of Pharmacy, Rohru, Shimla, Himachal Pradesh, India
4Jagran Lakecity University, Bhopal, Madhya Pradesh, India

Received 1 July 2014; Revised 20 August 2014; Accepted 22 August 2014; Published 14 October 2014

Academic Editor: Sunil K. Bajpai

Copyright © 2014 Peeyush Bhardwaj et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Multiple-unit-type oral floating hollow microspheres of 5-fluorouracil (5-Fu) were developed using modified solvent evaporation technique to prolong gastric residence time, to target stomach cancer, and to increase drug bioavailability. The prepared microspheres were characterized for micromeritic properties, floating behavior, entrapment efficiency, and scanning electron microscopy (SEM). The in vitro drug release and floating behavior were studied in simulated gastric fluid (SGF) at pH 1.2. The yield of microspheres was obtained up to %. Microspheres showed passable flow properties. Based on optical microscopy, particle size was found to be ranging from to m. SEM confirmed spherical size, perforated smooth surface, and a hollow cavity inside the microspheres. Different kinetic models for drug release were also applied on selected batches.