The Scientific World Journal
Volume 2014, Article ID 705259, 11 pages
http://dx.doi.org/10.1155/2014/705259
Research Article
Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting
1Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India
2NKBR College of Pharmacy & Research Centre, Meerut, Uttar Pradesh, India
3Government College of Pharmacy, Rohru, Shimla, Himachal Pradesh, India
4Jagran Lakecity University, Bhopal, Madhya Pradesh, India
Received 1 July 2014; Revised 20 August 2014; Accepted 22 August 2014; Published 14 October 2014
Academic Editor: Sunil K. Bajpai
Copyright © 2014 Peeyush Bhardwaj et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- A. F. Hofmann, J. H. Pressman, C. F. Code, and K. F. Witztum, “Controlled entry of oraly administered drugs: physiological considerations,” Drug Development and Industrial Pharmacy, vol. 9, no. 7, pp. 1077–1109, 1983. View at Publisher · View at Google Scholar · View at Scopus
- G. A. Agyilirah, M. Green, R. duCret, and G. S. Banker, “Evaluation of the gastric retention properties of a cross-linked polymer coated tablet versus those of a non-disintegrating tablet,” International Journal of Pharmaceutics, vol. 75, no. 2-3, pp. 241–247, 1991. View at Publisher · View at Google Scholar · View at Scopus
- S. Baumgartner, J. Kristl, F. Vrečer, P. Vodopivec, and B. Zorko, “Optimisation of floating matrix tablets and evaluation of their gastric residence time,” International Journal of Pharmaceutics, vol. 195, no. 1-2, pp. 125–135, 2000. View at Publisher · View at Google Scholar · View at Scopus
- E. Bulgarelli, F. Forni, and M. T. Bernabei, “Effect of matrix composition and process conditions on casein-gelatin beads floating properties,” International Journal of Pharmaceutics, vol. 198, no. 2, pp. 157–165, 2000. View at Publisher · View at Google Scholar · View at Scopus
- A. A. Deshpande, N. H. Shah, C. T. Rhodes, and W. Malick, “Development of a novel controlled-release system for gastric retention,” Pharmaceutical Research, vol. 14, no. 7, pp. 815–819, 1997. View at Publisher · View at Google Scholar · View at Scopus
- B. N. Singh and K. H. Kim, “Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention,” Journal of Controlled Release, vol. 63, no. 3, pp. 235–259, 2000. View at Publisher · View at Google Scholar · View at Scopus
- J. Timmermans and A. J. Moes, “Factors controlling the buoyancy and gastric retention capabilities of floating matrix capsules: new data for reconsidering the controversy,” Journal of Pharmaceutical Sciences, vol. 83, no. 1, pp. 18–24, 1994. View at Publisher · View at Google Scholar · View at Scopus
- J. Chen and K. Park, “Synthesis of fast-swelling, superporous sucrose hydrogels,” Carbohydrate Polymers, vol. 41, no. 3, pp. 259–268, 2000. View at Publisher · View at Google Scholar · View at Scopus
- Y. Akiyama, N. Nagahara, E. Nara et al., “Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites,” Journal of Pharmacy and Pharmacology, vol. 50, no. 2, pp. 159–166, 1998. View at Google Scholar · View at Scopus
- D. E. Chickering III, J. S. Jacob, T. A. Desai et al., “Bioadhesive microspheres: III. An in vivo transit and bioavailability study of drug-loaded alginate and poly(fumaric-co-sebacic anhydride) microspheres,” Journal of Controlled Release, vol. 48, no. 1, pp. 35–46, 1997. View at Publisher · View at Google Scholar · View at Scopus
- F. Kedzierewicz, P. Thouvenot, J. Lemut, A. Etienne, M. Hoffman, and P. Maincent, “Evaluation of peroral silicone dosage forms in humans by gamma-scintigraphy,” Journal of Controlled Release, vol. 58, no. 2, pp. 195–205, 1999. View at Publisher · View at Google Scholar · View at Scopus
- N. Rouge, E. Allémann, M. Gex-Fabry et al., “Comparative pharmacokinetic study of a floating multiple-unit capsule, a high-density multiple-unit capsule and an immediate-release tablet containing 25 mg atenolol,” Pharmaceutica Acta Helvetiae, vol. 73, no. 2, pp. 81–87, 1998. View at Publisher · View at Google Scholar · View at Scopus
- F. A. Johnson, D. Q. M. Craig, A. D. Mercer, and S. Chauhan, “The effects of alginate molecular structure and formulation variables on the physical characteristics of alginate raft systems,” International Journal of Pharmaceutics, vol. 159, no. 1, pp. 35–42, 1997. View at Publisher · View at Google Scholar · View at Scopus
- S. Desai and S. Bolton, “A floating controlled-release drug delivery system: in vitro-in vivo evaluation,” Pharmaceutical Research, vol. 10, no. 9, pp. 1321–1325, 1993. View at Publisher · View at Google Scholar · View at Scopus
- Y. Murata, N. Sasaki, E. Miyamoto, and S. Kawashima, “Use of floating alginate gel beads for stomach-specific drug delivery,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 50, no. 2, pp. 221–226, 2000. View at Publisher · View at Google Scholar · View at Scopus
- V. Iannuccelli, G. Coppi, M. T. Bernabei, and R. Cameroni, “Air compartment multiple-unit system for prolonged gastric residence, Part I: formulation study,” International Journal of Pharmaceutics, vol. 174, no. 1-2, pp. 47–54, 1998. View at Publisher · View at Google Scholar · View at Scopus
- M. Ichikawa, S. Watanabe, and Y. Miyake, “A new multiple-unit oral floating dosage system. I: preparation and in vitro evaluation of floating and sustained-release characteristics,” Journal of Pharmaceutical Sciences, vol. 80, no. 11, pp. 1062–1066, 1991. View at Publisher · View at Google Scholar · View at Scopus
- A. H. El-Kamel, M. S. Sokar, S. S. Al Gamal, and V. F. Naggar, “Preparation and evaluation of ketoprofen floating oral delivery system,” International Journal of Pharmaceutics, vol. 220, no. 1-2, pp. 13–21, 2001. View at Publisher · View at Google Scholar · View at Scopus
- Y. Kawashima, T. Niwa, H. Takeuchi, T. Hino, and Y. Itoh, “Hollow microspheres for use as a floating controlled drug delivery system in the stomach,” Journal of Pharmaceutical Sciences, vol. 81, no. 2, pp. 135–140, 1992. View at Publisher · View at Google Scholar · View at Scopus
- B. C. Thanoo, M. C. Sunny, and A. Jayakrishnan, “Oral sustained-release drug delivery systems using polycarbonate microspheres capable of floating on the gastric fluid,” Journal of Pharmacy and Pharmacology, vol. 45, no. 1, pp. 21–24, 1993. View at Publisher · View at Google Scholar · View at Scopus
- D.-P. Wang, M.-C. Yang, and C.-Y. Wong, “Formulation development of oral controlled-release pellets of diclofenac sodium,” Drug Development and Industrial Pharmacy, vol. 23, no. 10, pp. 1013–1017, 1997. View at Publisher · View at Google Scholar · View at Scopus
- H. Bechgaard, “Critical factors influencing gastrointestinal absorption: what is the role of pellets?” Acta Pharmaceutica Technologica, vol. 28, no. 2, pp. 149–157, 1982. View at Google Scholar · View at Scopus
- L. C. Feely and S. S. Davis, “Correlation of phenylpropanolamine bioavailability with gastrointestinal transit by scintigraphic monitoring of 111In-labeled hydroxypropylmethylcellulose matrices,” Pharmaceutical Research, vol. 6, no. 4, pp. 274–278, 1989. View at Publisher · View at Google Scholar · View at Scopus
- H. Bechgaard and K. Ladefoged, “Distribution of pellets in the gastrointestinal tract. The influence on transit time exerted by the density or diameter of pellets,” Journal of Pharmacy and Pharmacology, vol. 30, no. 11, pp. 690–692, 1978. View at Publisher · View at Google Scholar · View at Scopus
- Z. Rahman, K. Kohli, R. K. Khar, M. Ali, N. A. Charoo, and A. A. A. Shamsher, “Characterization of 5-fluorouracil microspheres for colonic delivery,” AAPS PharmSciTech, vol. 7, no. 2, pp. E47–E53, 2006. View at Publisher · View at Google Scholar · View at Scopus
- C. Zinutti, M. Barberi-Heyob, M. Hoffman, and P. Maincent, “In-vivo evaluation of sustained release microspheres of 5-FU in rabbits,” International Journal of Pharmaceutics, vol. 166, no. 2, pp. 231–234, 1998. View at Publisher · View at Google Scholar · View at Scopus
- S. Haznedar and B. Dortunç, “Preparation and in vitro evaluation of Eudragit microspheres containing acetazolamide,” International Journal of Pharmaceutics, vol. 269, no. 1, pp. 131–140, 2004. View at Publisher · View at Google Scholar · View at Scopus
- C. Paulo and M. S. L. Jose, “Modeling and comparison of dissolution profiles,” European Journal of Pharmaceutical Sciences, vol. 13, no. 2, pp. 123–133, 2001. View at Publisher · View at Google Scholar
- J.-H. Lee, T. G. Park, and H.-K. Choi, “Development of oral drug delivery system using floating microspheres,” Journal of Microencapsulation, vol. 16, no. 6, pp. 715–729, 1999. View at Publisher · View at Google Scholar · View at Scopus
- C. V. S. Subrahmanyam, Textbook of Physical Pharmaceutics, Vallabh Publication, Mumbai, India, 2nd edition, 2002.
- K. S. Soppimath, A. R. Kulkarni, and T. M. Aminabhavi, “Development of hollow microspheres as floating controlled-release systems for cardiovascular drugs: preparation and release characteristics,” Drug Development and Industrial Pharmacy, vol. 27, no. 6, pp. 507–515, 2001. View at Publisher · View at Google Scholar · View at Scopus
- A. Patel, S. Ray, and R. S. Thakur, “In-vitro evaluation and optimization of controlled release floating drug delivery system of metformin hydrochloride,” DARU, vol. 14, no. 2, pp. 57–64, 2006. View at Google Scholar · View at Scopus
- J. T. Fell and G. A. Digenis, “Imaging and behaviour of solid oral dosage forms in vivo,” International Journal of Pharmaceutics, vol. 22, no. 1, pp. 1–15, 1984. View at Publisher · View at Google Scholar · View at Scopus
- R. Bomma, R. S. Naidu, M. Yamsani, and K. Veerabrahma, “Development and evaluation of gastroretentive norfloxacin floating tablets,” Acta Pharmaceutica, vol. 59, no. 2, pp. 211–221, 2009. View at Publisher · View at Google Scholar · View at Scopus