Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting

Table 7

Drug release kinetics for different formulations.

Kinetic Model	Parameters	Formulation code
		G-1	G-2	G-3	G-4	G-5	G-6	G-7	G-8	G-9
Zero-order		0.344	0.403	0.497	0.485	0.647	0.533	0.467	0.617	0.355
	RSS	9221	7800	6307	5485	3925	6721	7536	5095	7632
		7.394	6.989	6.627	6.11	5.775	7.045	7.197	6.335	6.996
First-order		0.942	0.910	0.916	0.865	0.925	0.965	0.963	0.915	0.944
	RSS	0.893	1351	1271	1657	1175	653	685	1055	1287
		−0.204	−0.169	−0.145	−0.115	0.107	−0.176	−0.197	−0.123	−0.162
Higuchi		0.915	0.927	0.943	0.947	0.965	0.956	0.945	0.962	0.934
	RSS	1637	1304	849	797	434	8.203	997	629	1092
		27.344	25.747	24.336	22.457	21.001	25.813	26.433	23.102	25.794
Hixon-Crowell		0.846	0.816	0.823	0.785	0.853	0.897	0.886	0.844	0.846
	RSS	2672	2813	2404	2570	1842	1922	2125	1952	2726
		−0.042	−0.034	−0.037	−0.033	−0.025	−0.043	−0.046	−0.035	−0.035
Peppas and Korsmeyer		0.922	0.926	0.957	0.935	0.945	0.963	0.955	0.956	0.954
	RSS	11.836	959	584	642	472	504	552	683	417
		32.131	2991	28.183	25.123	21.366	30.165	32.065	23.482	33.812
		0.443	0.445	0.445	0.465	0.503	0.445	0.423	0.505	0.393
Best fit model		FO	M	PK	M	M	FO	FO	M	PK

RSS = Residual sum of squares
= Release constant
= Diffusion coefficient
ZO = Zero order
FO = First order
H = Higuchi
PK = Peppas Korsmeyer.